Choose the correct answers.
1. To understand the
drug receptor interaction it is necessary to quantify the relationship between
a) drug and its
toxicity b) drug
and its absorption
c) drug
and its biological effects
d) drug and its metabolic product
Q.2 Penicillinase
resistance penicillin is
a) Amoxicillin
b) Ampicillin c) Penicillin V d) Methicillin
Q.3 Morphine is present
in
a) Atropa
belladonna b) Papaver
somniferum c) Ricinus
communis d) Solanum nigrum
Q.4 Ion exchange
chromatography is the method of choice for the separation of
a) metals b) sugars c) Fatty acids d) Sterols
Q.5 Rideal-Walker test
is performed by using the strain
a) Escherichia coli b) Staphylococcus aureus c) Streptococcus pyogenes d) Salmonella typhi
Q.6 Pheniramine Malate
is an antihistaminic agent belonging to class
a) Ethylenediamine
derivatives b) Cyclic basic chain analogues
c) Aminoalkyl
ether analogues d)
none of these
Q.7 Tetracyclines
undergoes epimerization at C-4 between pH 4 and 8 to give
a) Isotetracyclines
b) Epitetracyclines c) Nortetracyclines d)
none of these
Q.8 Cimetidine inhibits
gastric secretion as a result of
a) Inhibition of H1
receptors b) Inhibition
of H2 receptors
c) Inhibition
of nicotinic receptors d) Inhibition of muscarnic
receptors
Q.9 For film coating,
the following ingredients are commonly used except
a) Povidone
b) polyethylene glycol c) Carnauba wax d) Hydroxypropylmethyl cellulose
Q.10 Tyndallisation
means
a) Successive autoclaving
with a bactericide b) Successive heating with a
bactericide
c) Successive heating
at low temperature d) Successive autoclaving at low temperature and
incubation
Q.11 Morphine and heroin
differ from each other in respect of
a) Methyl group on
nitrogen b) Acetyl
group at C3 & C6
c) absence
of double bond between C5 & C6 d) absence of D ring
Q.12 Vincristine and
vinblastine act by
a) Binding with the
protein tubulin and arrest at metaphase
b) Inhibiting the protein synthesis
c) Acting
as antometabolite d)
Inhibiting the enzyme system
Q.13 A rhamno-glucoside
on complete hydrolysis will give
a) Aglycone + Fructose
+ Rhamanose b)
Aglycone + Ribose + Rhamanose
c) Aglycone
+ Glucose + Rhamanose d) Fructose
+ Rhamanose
Q.14 The technique
employed to study the insoluble film at oil-water interface is
a) Micellization
b) Deflocculation c) Electrostatic balance d) Film balance
Q.15 Gray baby syndrome
is due to the indiscriminate use of
a) Streptomycin b) Chloramphenicol c) Penicillin d) Tetracycline
Q.16 N,
N-dimethyl-(1-methyl-4-oxo-3, 3-diphenylhexyl)-ammonium chloride is chemical
name for
a) Methadone
hydrochloride b) α-prodine
hydrochloride
c) Meperidine
hydrochloride
d) Darvon
Q.17 Sulponamide tragedy
was due to its combination with
a) Penicillin b) Streptomycin c) Diethylene glycol d) Bicarbonate
Q.18 In the preparation
of tablets, powdered medicaments are mixed by moistening
a) To reduce the total
volume b) To
increase adsorption
c) To
increase adhesiveness d) To reduce
inter-particulate friction
Q.19 One nanometer (nm)
is equal to
a) 10-5
cm b) 10-6
cm c) 10-7 cm d) 10-8 cm
Q.20 Cholinergic
receptor present on intestinal muscle is
a) H2-receptor b)
Muscarinic receptor c) Nicotinic
receptor d) β-receptor
Q.21 Indicate the
correct order of increasing eluent power of benzene, ether, chloroform and
ethyl acetate
a) Chloroform <
Benzene < Ethyl acetate < Ether
b) Benzene < Ether
< Chloroform < Ethyl acetate
c) Ether <
Chloroform < Ethyl acetate < Benzene
d) Ethyl
acetate < Ether < Benzene < Chloroform
Q.22 Limulus test is
rapid in vitro test for parenterals to detect the presence of
a) Particulate
matter b) Fungus c) Pyrogens d) Bacteria
Q.23 An essential requirement
for the mobile phase in the HPLC is that
a) It must have
constant flow rate with pulse less flow b) It must be freshly
distilled
c) It
must be ran at 200C only d)
It must flow with pulses
Q.24 Indian (Tinnevally)
and African senna leaves differ from each other with respect to
a) Vein-islet
number b) Stomatal
index c) Colour d) all of the above
Q.25 3-Etherification of
morphine molecule causes
a) Morphine antagonism
b)
No change in activity
c) Decrease
of analgesic and addiction
d) Increase of analgesic and addiction
Q.26 Addition of
electrolyte to a lyophilic sol may cause
a) Tyndall
effect b) Salting
out c) Coagulation d) Dilution
Q.27 Salicin, a phenolic
glycoside, on hydrolysis yields
a) Salicylic acid +
Glucose b)
Phenol + Glucose
c) Salicyl
alcohol + Glucose
d) Salicyl aldehyde + Glucose
Q.28 Lignocaine
hydrochloride is officially assayed by
a) Potentiometric
titration b) Acid base titration
c) Complexometric
titration d) Non aqueous titration
Q.29 In supra
ventricular arrhythmia, Digoxin when supplemented with…… is dangerous
a) Quinidine
b) Procaine c) Calcium d) Xylocaine
Q.30 Injection of
insulin I.P. should be kept at pH between
a) 5
and 5.5 b) 3 and 3.5 c) 7 and 7.5 d) 9 and 9.5
Q.31 Some
adrenocorticoids are referred to as Δ-corticoids because of
a) High amount of
Unsaturation in the molecule
b) Additional double
bond in each ring A between Carbon 1 and 2
c) Presence of one
double bond in each ring
d) presence
of double bond in ring A
Q.32 The preservative
used in the preparation of capsule is
a) Beta
naphthol b) Chorocresol c) Chloroxylenol d) Phenyl mercuric nitrate
Q.33 In radioactive
pharmaceuticals, half life (t1/2) of compound means
a) The time taken for
one of the compound to bind with serum albumin
b) The time taken for
onset of its action
c) The time taken for
the activity to decay to one-half of its initial value
d) The
time taken for its complete metabolism
Q.34 Wagner’s test is
used to detect the presence of
a) Steroids
b) Alkaloids c) Glycosides d) Terpenoids
Q.35 Metronidazole
inhibits anaerobic bacteria and protozoan by
a) Affecting the
structure of DNA molecule of the organism b) Destroying the ribosomes
c) inhibiting
the cytochrome system d)
Inhibiting the protein synthesis
Q.36 Most common
estrogen/progesterone preparations used as oral contraceptive agent contains
a) Mestranol +
Progesterone b) Estrone +
progesterone
c) Diethyl
stilbestrol + Norgestrel
d) Ethinyl estradiol + Norethindrone
Q.37 Peripheral
neurotransmitter is
a) Histamine
b) Noradrenaline c) Hydroxytriptamine d) Prostaglandin
Q.38 Beer’s Law states
that
a) Absorbance of a
solution is indirectly proportional to the concentration of the absorbing
solute b) Absorbance of a solution is indirectly proportional to the
length of the cell
c) Absorbance of a
solution is directly proportional to the concentration of the absorbing solute d)
Transmittance of a solution is directly proportional to the absorbing
solvent
(2) Q.1 Given below are the hypotensive agents. Match their mode
of action (from a to e)
2.i.1 Minoxidil
a) α-adreno
receptor anatagonist
2.i.2 Prazosin
b) β-adreno
receptor anatagonist
2.i.3 α-methyl
Dopa c) Forms α-methyl norepinephrine
2.i.4 Clonidine
d) Direct
action on blood vessel (vasodilatation)
e) Decrease
sympathetic activity through brain
Q.2 Indicate from group
a to e the correct compound for the given source
2.ii.1 Urginea
maritima a) Camphene
2.ii.2 Rheum
Palmatum b) Scilliroside
2.ii.3 Myristica
fragrans c) Emodine
2.ii.4 Claviceps
purpurea d) Atropine
e) Ergometrine
Q.3 Select the
appropriate pH range from a to e for the following indicators
2.iii.1 Methyl
red a) 1.2
– 2.8
2.iii.2 Bromothymol
blue b) 4.2 – 4.6
2.iii.3 Phenolphthalein
c) 4.8 – 5.2
2.iii.4 Thymol
blue d) 8.2
– 10.0
e)
6.0 – 7.6
Q.4 Given drugs and
their schedules a to e. Match them correctly
2.iv.1 B-complex
tablets a) Schedule
C1
2.iv.2 Calcium
gluconate injection b) Schedule F
2.iv.3 Small
pox vaccine c) Schedule H
2.iv.4 Ampicillin
capsules d) Schedule L
e) Schedule C
Q.5 Given below are the
antibacterial agents and probable mode of action (a to d).
2.v.1 Gentamycin
a) Inhibits
the mycolic acid synthesis
2.v.2 Isoniazid
b) Prevents
the bacterial cell wall synthesis
2.v.3 Polymixin
B c) Binds
with 30 S ribosomal sub-unit (takes false amino acid)
2.v.4 Penicillin d) Destroy the
nucleic acid
Q.6 Match the given
ingredients from a to e with the purpose for it is incorporated in the
formulation
of tablets.
2.vi.1 Glident a) Starch
2.vi.2 Diluent
b) Stearic
acid
2.vi.3 Adherent c) Talc
2.vi.4 Disintegrant
d) Lactose
e) Acacia
Q.7 Match the given
heterocyclic ring given with their compounds
2.vii.1 Glutethemide a) Imidazoline ring
2.vii.2 Clonidine b) Piperidine ring
2.vii.3 Ketoconazole
c) Indene
ring
2.vii.4 Sulindac
d) 1, 3-dioxane ring
e) Indole ring
Q.8 Given blow are the
aliments and the drugs used (a to e). Match them correctly.
2.viii.1 Parkinson’s
disease a) Probenecid
2.viii.2 Glaucoma b) Ampicillin
2.viii.3 Gout c) Nitroglycerine
2.viii.4 Angina d) Pilocarpine
e) Levodopa
Q.9 Given below are the
equipments used in manufacturing of powder and their purposes
(a
to e). Match them correctly
2.ix.1 Coulter
counter a) To
determine the total surface
2.ix.2 Sorptometer
b) To
determine the particle size
2.ix.3 Andreasen
apparatus c) To
determine the flow rate
2.ix.4 Shear
box d) To
determine sedimentation rate
e) To determine the
cohesiveness
Q.10 Match the following
from a to e.
2.x.1 Photocell
can be prevented from getting fatigue a) By selecting excitation and
visible
wavelength
2.x.2 Resolving
power of grating b) By exposing to radiation for minimal
can be increased possible
time
2.x.3 Two
different color compounds c) By increasing the
number of lines per
can be analyzed mm/using
high order
2.x.4 λmax
can be found d) After
separation/using binary component system
e) By finding the
absorbance at each wavelength
Q.11 Choose the
appropriate drug from a to e for following categories:
2.xi.1 Alkylating
agent a) Colchicine
2.xi.2 Carcinogen
b) 6-mercaptopurine
2.xi.3 Antimitotic
agent c) Cyclopentamine
2.xi.4 Antimetabolite
d) Thio-TEPA
e) Aflotoxin-B1
Q.12 Choose the correct
synonymous words a to e for the given type of stomata
2.xii.1 Anomocytic
a) Caryophyllaceous
2.xii.2 Anisocytic
b) Rubiaceous
2.xii.3 Diacytic
c) Ranunculaceaus
2.xii.4 Paracytic
d) Solanaceous
e) Cruciferous
Q.13 Given below are the
drugs and their antagonists (a to e). Match them correctly.
2.xiii.1 5-HT1 a) Bemegride
2.xiii.2 Codeine b) Atropine
2.xiii.3 Phenobarbitone c) Cyperoheptadine
2.xiii.4 Muscarine
d) Naloxone
e) Pyridoxine
Q.14 Select the
appropriate color from a to e for the given wave length
2.xiv.1 450 –
480 nm a) Green
2.xiv.2 500 –
560 nm b) Yellow
2.xiv.3 574 –
590 nm c) Blue
2.xiv.4 625 –
750 nm d) Orange
e) Red
Q.15 Match the
solubility range from a to e as per I.P. with following.
2.xv.1 Freely
soluble a) Less than 1
part
2.xv.2 Soluble b) 1 to 10 parts
2.xv.3 Sparingly
soluble c) 10 to 30 parts
2.xv.4 Slightly
soluble d) 30 to 100 parts
e)
100 to 1000 parts
Q.16 Given below are the
drugs and their enzymes (a to e) inhibited by them.
2.xvi.1 Physostigmine
a) COMT
2.xvi.2 Imipramine b) Acetaldehyde dehydrogenase
2.xvi.3 Pyrogallol
c) Carbonic
anhydrase
2.xvi.4 Disulfiram
d) Cholinesterase
e) MAO
Q.17 According drug and
cosmetic rules a list of schedules are given and match the
appropriate
statement with them
2.xvii.1 Schedule
P a) Drugs used
under medical supervision
2.xvii.2 Schedule
W b) Drugs marketed
under generic name only
2.xvii.3 Schedule
N c) Minimum
equipments needed for retail pharmacy
2.xvii.4 Schedule
J d) Disease that
a drug should not claim to cure
e)
Life period of drugs
Q.18 Given below are the
drugs and their structural moiety a to e responsible for the
biological
action. Match them correctly.
2.xviii.1 Diphenhydramine
a) Lactone ring
2.xviii.2 Acetylcholine
b) Substitution
at C5 of barbituric acid
2.xviii.3 Penicillin
c) Onium
group
2.xviii.4 Gardinal
d) Beta
lactam ring
e) 2-aminomethyl side chain
Q.19 Given below are the
diuretics and their possible mode of action a to e.
2.xix.1 Acetazolamide
a) Affecting the
osmosis
2.xix.2 Furosemide
b) Inhibits
the active transport of Cl- at ascending loop of Henle
2.xix.3 Triamterene c) Inhibits the
reabsorption of Na+ in mineralo corticoid
dependent portion of renal tubule
2.xix.4 Mannitol
d)
Carbonic anhydrase inhibitor
e) Causing acidosis
Q.20 Match the
biological activity a to e for the following compounds.
2.xx.1 4,
5-di-(hydroxymethyl) -3-hydroxy)-2-methyl pyridine a) Sympathomimetic
2.xx.2 (3-dibutyraminopropyl)-4-aminobenzoate
b) CNS
stimulant
2.xx.3 2-hydroxy-2-(3’,
4’-dihydroxyphenyl)-ethylamine c) Sedative/hypnotics
2.xx.4 1-methyl-2phenylethylamine
d) Vit. B6
e) Local anesthetic
Answer Key-1988 (Multiple Choice)
1.c 2.d 3.b 4.a 5.d 6.d 7.b 8.b 9.c 10.c 11.b 12.a
13.c 14.d 15.b 16.a 17.a 18.c 19.c 20.b 21.b 22.c 23.a 24.d 25.c 26.b 27.c 28.d
29.a 30.a 31.a 32.b 33.c 34.b 35.a 36.d 37.b 38.c
Match the column
1. (1) d (2) a (3) c (4) e 2. (1) b (2) c (3) a (4)
e 3. (1) b (2) e (3) d (4) a
4. (1) a (2) b (3) e (4) c 5. (1) c (2) a (3) d (4)
b 6. (1) c (2) d (3) e (4) a
7. (1) b (2) a (3) d (4) c 8. (1) e (2) d (3) a (4) c 9. (1) b (2) a (3) d (4)
c 10. (1) b (2) c (3) d (4) e 11. (1) d (2) e (3) a (4)
b 12.
(1) c (2) e (3) a (4) b
13. (1) c (2) d (3) a (4) b 14. (1)
c (2) a (3) b (4) e 15.
(1) b (2) c (3) d (4) e 16. (1)
d (2) e (3) a (4) b 17. (1) e (2) b (3) c (4) d 18. (1) e (2) c (3) d (4) b
19. (1) d (2) b (3) c (4) a 20. (1) d (2) e (3) a (4) b
No comments:
Post a Comment