001.
Acetylcholine is not a specific neurotransmitter at:
a)
Sympathetic ganglia b)
Sympathetic postganglionic nerve endings
c)
Parasympathetic ganglia d)
Parasympathetic postganglionic nerve endings
002.
Muscarinic receptors are located in:
a)
Autonomic ganglia b)
Skeletal muscle neuromuscular junctions
c)
Autonomic effector cells d)
Sensory carotid sinus baroreceptor zone
003.
Indicate the location of M2 cholinoreceptor type:
a)
Heart b) Glands c) Smooth muscle d) Endothelium
004.
The symptoms of mushroom poisoning include all of the following EXCEPT:
a)
Salivation, lacrimation, nausea, vomiting b)
Dryness of mouth, hyperpyrexia, hallucination
c)
Headache, abdominal colic d)
Bradycardia, hypotension and shock
005.
Which of the following cholinomimetics activates both muscarinic and nicotinic
receptors?
a)
Lobeline b) Pilocarpine c) Nicotine d) Bethanechol
006.
Indicate a cholinomimetic agent, which is related to direct-acting drugs:
a)
Edrophonium b) Physostigmine c) Carbachol d) Isoflurophate
007.
Characteristics of carbachol include all of the following EXCEPT:
a)
It decreases intraocular pressure b)
It causes mydriasis
c)
It exerts both nicotinic and muscarinic effects d) It is resistant to acethylcholiesterase
008.
Acetylcholine is not used in clinical practice because:
a)
It is very toxic b)
The doses required are very high
c)
It is very rapidly hydrolyzed d)
It is very costly
009.
Parasympathomimetic drugs cause:
a)
Bronchodilation b)
Mydriasis c) Bradycardia d) Constipation
010.
Which of the following direct-acting cholinomimetics is mainly muscarinic in
action?
a)
Bethanechol b)
Carbachol c) Acetylcholine d) None of the above
011.
Which of the following direct-acting cholinomimetics has the shortest duration
of action?
a)
Acetylcholine b)
Methacholine c) Carbachol d) Bethanechol
012.
Bethanechol has all of the following properties EXCEPT:
a)
It is extremely resistant to hydrolysis b) Purely muscarinic in its action
c)
It is used for abdominal urinary bladder distention
d)
It exerts both nicotinic and muscarinic effects
013.
A M-cholinimimetic agent is:
a)
Carbachol b)
Pilocarpine c) Acetylcholine d)
Bethanechol
014.
Characteristics of pilocarpine include all of the following EXCEPT:
a)
It is a tertiary amine alkaloid
b)
It causes miosis and a decrease in intraocular pressure
c)
Causes a decrease in secretory and motor activity of gut
d)
It is useful in the treatment of glaucoma
015.
Which of the following cholinomimetics is a plant derivative with lower potency
than nicotine but with a similar spectrum of action?
a)
Lobeline b) Pilocarpine c) Carbochol d) Acetylcholine
016.
Which of the following cholinomimetics is indirect-acting?
a)
Lobeline b) Edrophonium c) Pilocarpine d) Carbachol
017.
The mechanism of action of indirect-acting cholinomimetic agents is:
a)
Binding to and activation of muscarinic or nicotinic receptors
b)
Inhibition of the hydrolysis of endogenous acetylcholine
c)
Stimulation of the action of acetylcholinesterase
d)
Releasing acetylcholine from storage sites
018.
Indicate a reversible cholinesterase inhibitor:
a)
Isoflurophate b)
Carbochol c) Physostigmine d) Parathion
019.
Which of the following cholinesterase inhibitors is irreversible?
a)
Physostigmine b)
Edrophonium c) Neostigmine d) Isoflurophate
020.
Indicate cholinesterase activator:
a)
Pralidoxime b)
Edrophonium c) Pilocarpine d) Isoflurophate
021.
Isofluorophate increases all of the following effects except:
a)
Lacrimation b)
Bronchodilation c) Muscle twitching d) Salivation
022.
Indicate a cholinesterase inhibitor, which has an additional direct nicotinic
agonist effect:
a)
Edrophonium b)
Carbochol c) Neostigmine d) Lobeline
023.
Cholinesterase inhibitors do not produce:
a)
Bradycardia, no change or modest fall in blood pressure
b)
Increased strength of muscle contraction, especially in muscles weakened by myasthenia
gravis
c)
Miosis and reduction of intraocular pressure d)
Dramatic hypertension and tachycardia
024.
Which of the following cholinomimetics is commonly used in the treatment of
glaucoma?
a)
Pilocarpine b) Lobeline c) Acethylcholine d) Neostigmine
025.
Indicate the organophosphate cholinesterase inhibitor, which can be made up in
an aqueous solution for ophthalmic use and retains its activity within a week:
a)
Physoctigmine b)
Edrophonium c) Echothiophate d) Neostigmine
026.
Which of the following cholinomimetics is most widely used for paralytic ileus
and atony of the urinary bladder?
a)
Lobeline b) Neostigmine c) Pilocarpine d) Echothiophate
027.
Chronic long-term therapy of myasthenia is usually accomplished with:
a)
Edrophonium b) Neostigmine c) Echothiophate d) Carbachol
028.
Which of the following cholinomimetics is a drug of choice for reversing the
effects of nondepolarizing neuromuscular relaxants?
a)
Echothiophate b) Physostigmine c) Edrophonium d) Pilocarpine
029.
Indicate the reversible cholinesterase inhibitor, which penetrates the
blood-brain barrier:
a)
Physostigmine b) Edrophonium c) Neostigmine d) Piridostigmine
030.
Which of the following cholinomimetics is used in the treatment of atropine
intoxication?
a)
Neostigmine b) Carbochol c) Physostigmine d) Lobeline
031.
The symptoms of excessive stimulation of muscarinic receptors include all of
the following EXCEPT:
a)
Abdominal cramps, diarrhea b) Increased salivation, excessive
bronchial secretion
c)
Miosis, bradycardia d)
Weakness of all skeletal muscles
032.
The excessive stimulation of muscarinic receptors by pilocarpine and choline
esters is blocked competitively by:
a)
Edrophonium b)
Atropine c) Pralidoxime d) Echothiophate
033.
The toxic effects of a large dose of nicotine include all of the following
EXCEPT:
a)
Hypotension and bradycardia b)
Convulsions, coma and respiratory arrest
c)
Skeletal muscle depolarization blockade and respiratory paralysis
d)
Hypertension and cardiac arrhythmias
034.
The dominant initial sights of acute cholinesterase inhibitors intoxication
include all of the following except:
a)
Salivation, sweating b)
Mydriasis c) Bronchial constriction d) Vomiting and diarrhea
035.
Which of the following drugs is used for acute toxic effects of organophosphate
cholinesterase inhibitors?
a)
Atropine b)
Pilocarpine c) Pralidoxime d)
Edrophonium
|
1.b
|
6.c
|
11.a
|
16.b
|
21.b
|
26.b
|
31.d
|
|
2.c
|
7.b
|
12.d
|
17.b
|
22.c
|
27.b
|
32.b
|
|
3.a
|
8.c
|
13.b
|
18.c
|
23.d
|
28.c
|
33.a
|
|
4.b
|
9.c
|
14.c
|
19.d
|
24.a
|
29.a
|
34.b
|
|
5.d
|
10.a
|
15.a
|
20.a
|
25.c
|
30.c
|
35.c
|
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