Q 1.Vasodilation by
histamine is mediated via?
A). H2 B). H3 C). H1 D). Both A and C
A). H2 B). H3 C). H1 D). Both A and C
Ans. D
Q 2 .Oxytocin is a?
A). Octapeptide B). Heptapeptide C). Decapeptide D). Pentapeptide
A). Octapeptide B). Heptapeptide C). Decapeptide D). Pentapeptide
Ans. (A) Octapeptide, if you not find Nonapeptide in
option than correct answer (A) Octapeptide
Read carefully>>>> Oxytocin is a peptide of nine amino acids (a nonapeptide).
Its systematic name is cysteine-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycine-amide (cys – tyr – ile – gln – asn – cys – pro – leu – gly – NH2, or CYIQNCPLG-NH2).
The biologically active form of oxytocin, commonly measured by Radioimmunoassay and/or High-performance liquid chromatography techniques, is also known as the octapeptide "oxytocin disulfide" (oxidized form), but oxytocin also exists as a reduced dithiol nonapeptide called oxytoceine.
Read carefully>>>> Oxytocin is a peptide of nine amino acids (a nonapeptide).
Its systematic name is cysteine-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycine-amide (cys – tyr – ile – gln – asn – cys – pro – leu – gly – NH2, or CYIQNCPLG-NH2).
The biologically active form of oxytocin, commonly measured by Radioimmunoassay and/or High-performance liquid chromatography techniques, is also known as the octapeptide "oxytocin disulfide" (oxidized form), but oxytocin also exists as a reduced dithiol nonapeptide called oxytoceine.
Q 3. Bactericidal inhibitor of Protein synthesis is?
A). Penicillin-G B). Erythromycin C). Gentamycin D). Tetracyclin
Ans. C, Gentamycin, Amikacin, Netilmicin, Spectinomycin (Aminoglycosides class) inhibition of protein synthesis by binding to 30s ribosomal subunit (killing bacterial cell-Bactericidal). Erythromycin (Bacteriostatic, Narrow-spectrum) & Tetracyclin (Bacteriostatic, Broad-spectrum) act by reversible inhibition of protein synthesis by action on ribosomes. Penicillin-G (Bactericidal, Narrow-spectrum) act by inhibition of synthesis of cell-wall (Inhibit polymerization Enzyme- transpeptidase.
A). Penicillin-G B). Erythromycin C). Gentamycin D). Tetracyclin
Ans. C, Gentamycin, Amikacin, Netilmicin, Spectinomycin (Aminoglycosides class) inhibition of protein synthesis by binding to 30s ribosomal subunit (killing bacterial cell-Bactericidal). Erythromycin (Bacteriostatic, Narrow-spectrum) & Tetracyclin (Bacteriostatic, Broad-spectrum) act by reversible inhibition of protein synthesis by action on ribosomes. Penicillin-G (Bactericidal, Narrow-spectrum) act by inhibition of synthesis of cell-wall (Inhibit polymerization Enzyme- transpeptidase.
Q 4. Antagonist for
Pyridoxine (vitamin B6) is?
A). Cycloserine B). Hydralazine C). Penicillamine D). All of the above
Note:- Pyridoxine also used in treatment of Organophosphate poisoning.
A). Cycloserine B). Hydralazine C). Penicillamine D). All of the above
Note:- Pyridoxine also used in treatment of Organophosphate poisoning.
Ans. D
Q 5. Ammonium bromide (82Br) injection is used for?
A). Thyroid scanning and study of thyroid uptake
B). Study of iron metabolism and RBC formation
C). Treatment of polycythema vera (overproduction of RBC)
D). Extracellular water measurement
A). Thyroid scanning and study of thyroid uptake
B). Study of iron metabolism and RBC formation
C). Treatment of polycythema vera (overproduction of RBC)
D). Extracellular water measurement
Ans. D Extracellular water measurement
Q 6. Dimercaprol (BAL) is used for poisoning of?
A). Antimony B). Lead C). Arsenic D). All
Ans. D
Note:-BAL (British anti-lewisite) = 2,3-dimercaptopropanol is also used for Gold (Au), Murcury (Hg) and other toxic metal poisoning ¤
A). Antimony B). Lead C). Arsenic D). All
Ans. D
Note:-BAL (British anti-lewisite) = 2,3-dimercaptopropanol is also used for Gold (Au), Murcury (Hg) and other toxic metal poisoning ¤
Q 7 . Sigma blade mixers are commonly used in? A).
Wet granulation B). Powder mixing C). Crude fibre mixing D). Dry granulation
Ans = A , Sigma blade mixer (agitator) most commonly
used mixer for mixing semisolids of plastic consistences.
Q 8. Ergot powder gives blue colour with: A).
Wagner's reagent B).Ferric chloride C).Mayer's reagent D).
p-Dimethylaminobenzaldehyde
Ans = D, (p-Dimethylaminobenzaldehyde )
Van Urk's test (for Ergot Alkaloids) = Test for Ergotoxin
Extract with CHCl3 and Na2CO3 → Separate CHCl3 layer → 0.1 g p-Dimethylaminobenzaldehyde + 100 ml 35 % H2SO4 + 1.5 ml 5 % FeCl3 → Blue colour
Van Urk's test (for Ergot Alkaloids) = Test for Ergotoxin
Extract with CHCl3 and Na2CO3 → Separate CHCl3 layer → 0.1 g p-Dimethylaminobenzaldehyde + 100 ml 35 % H2SO4 + 1.5 ml 5 % FeCl3 → Blue colour
Q 9. The Krabbe’s
disease result in the deficiency of the enzyme
a) Galactocerebrosidase b) hexosaminidase
c) Sphingomylase d) Tyrosinase
a) Galactocerebrosidase b) hexosaminidase
c) Sphingomylase d) Tyrosinase
Ans = A
Krabbe disease (also known as globoid cell leukodystrophy or galactosylceramide lipidosis) is a rare, often fatal degenerative disorder that affects the myelin sheath of the nervous system. It is a form of sphingolipidosis, as it involves dysfunctional metabolism of sphingolipids. This condition is inherited in an autosomal recessive pattern.
Galactosylceramidase (or galactocerebrosidase) is an enzyme that in humans is encoded by the GALC gene. Galactosylceramidase is an enzyme which removes galactose from ceramide derivatives (galactocerebrosides). Galactosylceramidase is a lysosomal protein which hydrolyzes the galactose ester bonds of galactocerebroside, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.
Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy.
Krabbe disease (also known as globoid cell leukodystrophy or galactosylceramide lipidosis) is a rare, often fatal degenerative disorder that affects the myelin sheath of the nervous system. It is a form of sphingolipidosis, as it involves dysfunctional metabolism of sphingolipids. This condition is inherited in an autosomal recessive pattern.
Galactosylceramidase (or galactocerebrosidase) is an enzyme that in humans is encoded by the GALC gene. Galactosylceramidase is an enzyme which removes galactose from ceramide derivatives (galactocerebrosides). Galactosylceramidase is a lysosomal protein which hydrolyzes the galactose ester bonds of galactocerebroside, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.
Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy.
Q 10. Prolonged administration of following drug
causes hoarseness of voice
a) Propranolol b) Thiazides c) Neuroleptics d) Corticosteroids
a) Propranolol b) Thiazides c) Neuroleptics d) Corticosteroids
answer = D
The corticosteroids that are inhaled to treat asthma today are considered safe. This is because the medicine, which is breathed in through a puffer, goes directly into the lungs where it reduces inflammation in the airways. A steroid tablet that is swallowed has more side effects because a large amount goes into the blood stream and is carried to other parts of the body. Side effects from inhaled corticosteroids are minor when the proper amount is taken. A few people get a cough, hoarseness or husky voice, sore throat or thrush (a yeast infection). Patients can protect against these discomforts by rinsing their mouth, gargling with water and spitting out, to remove any medicine left in the mouth.
The corticosteroids that are inhaled to treat asthma today are considered safe. This is because the medicine, which is breathed in through a puffer, goes directly into the lungs where it reduces inflammation in the airways. A steroid tablet that is swallowed has more side effects because a large amount goes into the blood stream and is carried to other parts of the body. Side effects from inhaled corticosteroids are minor when the proper amount is taken. A few people get a cough, hoarseness or husky voice, sore throat or thrush (a yeast infection). Patients can protect against these discomforts by rinsing their mouth, gargling with water and spitting out, to remove any medicine left in the mouth.
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