(1). Choose the correct answers.
Q.1 Reserpine on hydrolysis gives
a) Reserpic acid + Methyl alcohol +
Trimethoxy Cinnamic acid
b) Reserpic acid + Acetic acid + Trimethoxy
Benzaldehyde
c) Reserpic acid + Methyl alcohol +
Trimethoxy Benzoic acid
d) Reserpic acid + Methyl alcohol +
Trimethoxy Cinnamaldehyde
Q.2 Papaverine is
a) 6,7-dimethoxy-1-(3’-4’-dimethoxy benzyl)
isoquinoline
b) 6,7-dimethoxy-1-(3’-4’-dimethyl benzyl)
isoquinoline
c) 6,7-dimethoxy-1-(3’-4’-dimethoxy
benzyl)quinoline
d) 6,7-dimethyl-1-(3’-4’-dimethyl benzyl)
isoquinoline
Q.3 Titanium dioxide is commonly present in
a) Vanishing cream b) Sun screen cream c) Aqueous calamine cream d) Ophthalmic cream
Q.4 Powdered ergot when treated with sodium
hydroxide solution develops
a) A strong odour of ammonia b) A strong odour of trimethylamine
c) A
strong odour of indole d) A strong odour of urea (Trease &
Evans, 15th edition, page no 374)
Q.5 Salbutamol sulphate I.P. is assayed by
a) Direct titration with standard sodium
hydroxide solution
b) Direct titration with standard solution of
hydrochloric acid
c) A known amount of standard acid is added and
excess is titrated with standard alkali
d) Dissolve in glacial acetic acid and titrated
with standard perchloric acid using orcets blue
Q.6 Heparin prevents blood coagulation by
a) Inhibiting thrombin catalyzed conversion
of fibrinogen to fibrin
b)
precipitate blood calcium thereby prevent coagulation reaction
c) Inhibiting enzyme reaction d) Converting ionized calcium into
chelation
Q.7 For the registration of pharmacists in
the various states, the Pharmacy Act provides for the constitution
a) Registration Tribunals b)
Registrar of Co-operative societies
c) Registrar of State Pharmacy Council d) Registrar of Central Pharmacy
Council
Q.8 Powdered digitalis is dried at a
temperature
a) Not exceeding 600C b) 650C c) 750C d) 1000C
Q.9 Pranzepam differs in structure from
diazepam by
a) N-methyl group b) N-cyclopropyl group
c) N-cyclopropylmethyl group d) N-propyl group
Q.10 The mechanism of action of Rifampicin
involves
a) Inhibition of bacterial DNA-directed RNA
polymerase
b) Inhibition of mycolic acid synthesis
c) Inhibition of protein synthesis d) Inhibition of
transpeptidase
Q.11 The UV-Visible region in the
electromagnetic spectrum of radiation is
a) 200 - 400 nm b) 300 - 600 nm c) 400 - 800
nm d) 200 - 800 nm
Q.12 The Mantoux test uses
a) Old tuberculin test b) Diphtheria toxin c) Serum albumin d) Polysaccharide antigen
Q.13 Rotosort is a machine used to sort out
a) Coated tablets b)
Filled capsule c) Sealed
ampoules d) Sealed containers
Q.14 The volume of distribution of a drug is
a) An expression of total body volume b) A measure of total fluid
volume
c) A relationship between the total amount of
drug in the body and the concentration of the drug in the blood d)
proportional to bioavailability of the drug
Q.15 Resolution of a spectrophotometer is
a) Its wavelength range b) Its stability to distinguish adjacent
absorption bands
c) Its capacity for its continuous use d) Its powder to gather light according
to source
Q.16 Haloperidol is major tranquilizer. It
belongs to the class of
a) Carbamate b) Propanediol c) Butyrophenone d) Phenothiazine
Q.17 Glandular hairs having a unicellular or
occasionally a short uniserate pedical with a unicellular or bicellular
terminal gland is characteristic of
a) Senna leaves b) Belladonna leaves c) Datura stramonium leaves
d) Digitalis purpurea leaves (Trease &
Evans, 15th edition, page no 307)
Q.18Skeletal muscle relaxation produced by
the drug....is effectively antagonized by neostigmine
a) Diazepam b) Succinylcholine c) Tubocurarine d) Aminophylline
Q.19 Vitamin D3 is
a) 22, 23-dihydro-5, 6-cis-ergocalciferol b) 5,
6-cis-cholcalciferol
c) 7-dehydrocalciferol d)
21, 24-dihydro-5, 6-cis-ergocalciferol
Q.20 R.W.C. is used to identify the strength
of an
a) Antibiotic b) Antipyretic c) Antiseptic d) Anti-inflammatory
Q.21 The effective property of solution is
related to the
a) total number of solute particles b) pH c) Number of ions d) number of ingredients
Q.22 The essential structural unit for the
anthelmintic activity of Mebendazole is
a) Benzoyl group b) Benzimidazole c) Methylcarbamate d) Imidazole
Q.23 The anticoagulant activity of Heparin
Sodium Injection I.P. is estimated by using
a) Female rat b) Male dog c) Rabbit d) Sheep
Q.24 The biological half-life of a drug
(first order kinetic) is represented by
a) 1/k b) log k c) 0.693/k d) 2.303/k
Q.25 Infra-red spectrometry is a convenient
method for understanding of
a) Drug receptor interaction b) Functional group
Identification
c) Physio-chemical properties d) Conformational properties
Q.26 Most commonly used antimicrobial agent
for intraperitoneal dialysis fluid is
a) Chorocresol b) Bezalkonium chloride c) Isopropyl alcohol d) None of these
Q.27 In the steroid nucleus, there are
a) Six chiral centre with nucleus i.e. 5, 8,
9, 10, 13 and 14
b) Seven chiral centre with nucleus i.e. 3,
8, 9, 10,11, 12, 13 and 14
c) Six chiral centre with nucleus i.e. 3, 8,
9, 10, 11 and 12
d) Six chiral centre with nucleus i.e. 5, 7,
9, 10, 13 and 14
Q.28 Thermo labile immiscible liquid can be
separated by
a) Decantation b) Dilution c)
Capillary centrifugation d) Counter-current distribution
Q.29 Sulphamethoxazle is an antibacterial
drug it is a
a)short acting drug b)short & intermediate acting drug c)long acting drug d)mixed acting drug
Q.30 Wave number is the number of waves
a) per second b) per centimeter c) per inch d) per centimeter2
Q.31 The raw material for the synthesis of
Propranolol is
a) α-naphthylamine b) β-naphthol c) α-naphthol d) 1-naphthaldehyde
Q.32 All the statements mentioned below about
chloral hydrate is true except that is
a) Produce hypnosis b) Produce analgesia c) Produce dependence d) Irritates gastric
mucosa
Q.33 In Drug and Cosmetics Act and Rules
there under list of substances that should be sold by retail only on
prescription of Registered Medical Practitioner is given in:
a) Schedule H b) Schedule V c) Schedule X d) Schedule Q
Q.34 Which is the ideal combination for
testing the solubility of an enteric coating
capsule in alkaline medium?
a) Sodium bicarbonate + Potassium hydroxide +
Pepsin
b) Sodium bicarbonate + Sodium
tauroglycocholate + Pepsin
c) Sodium bicarbonate + Pancreatin + Sodium Tauroglycocholate
d)
Sodium bicarbonate + Bilirubin
Q.35 Oxazepam is used in the relief of
psychoneurosis. It has lower incidences of side
effects and reduced toxicity due to:
a) N-demethylation b) Ring oxidation
c) Aromatic hydroxylation d) Conjugation of 3- hydroxyl
group
Q.36 The rate of diffusion of drugs across
biological membrane is
a) directly proportional to the concentration
gradient b) dependent on the route of administration
c) Indirectly proportional to membrane thickness d) none of these
Q.37 In sugar coating of tablets, sub-coating
is done
a) To prevent moisture absorption b) To round the edges and built
tablet size
c) To smoothen the surface d) To prevent the tablet
from breaking due to vibration
Q.38 One of the detector is used in gas
chromatography is
s) Bolometer
b) Thermal conductivity detector c)
Golay detector d) Geiger counter
Q.39 Alkaloid in cinchona bark are detected
by
a) Iodine test b) Thalloquin test c)
Leibermann-Burchard test d) Nessler;s
test
Q.40 2-amino-5-chloro benzophenone is
convenient starting material for the synthesis of:
a) Nitrazepam b) Diazepam c) Chloramphenicol d) Trimethoprim
(2) Match
the following
Q.1 Given below are some of the association
colloids. Match the correct type from the list a to e.
1) Sodium lauryl sulphate a) Anionic
2) Cetyl trimethyl ammonium bromide b) Cationic
3) Polyethylene lauryl sulphate c)
Nonionic
4) Dimethyl dodecyl ammonia propane sulphate d) Ampholytic
e) none
Q.2 Given below are the essential
pharmacophores for the drugs mentioned from a to e.
1) 1, 4-benzodiazepine a)
Pindolol
2) β-lactam fused with thiozolidine b) Amoxicillin
3) Ethylenediamine c)
Ethambutol
4) Aryloxypropanolamine d)
Salbutamol
e)
Oxazepam
Q.3 The drugs mentioned below are produced by
species mentioned from a to e.
1) Rifampicin a) Streptomyces
griseus
2) Nystatin b) Bacillus polymyxa
3) Amphotericin B c) Streptomyces mediterranei
4) Candicidin d) Streptomyces nodosus
e) Streptomyces noursei
Q.4 Given below are the some important drugs.
Find out the correct constituents listed a to e derived from them
1) Cephaelis Ipecacuanha a) Cineole
2) Papaver somniferum b) Safrole and
Myristicin
3) Cascara sagrada c) Morphine
4) Myristica fragrans d) Anthraquinone
glycosides
e) Emetine
Q.5 The side chain responsible for the
biological activity of drug listed from a to e are given
1) .NH-(CH3)CH-CH2-CH2-CH2-N(C2H5)2
a)
Amodiaquine
2) .CH2-CH2-SO2-CH2-CH3
b)
Tinidazole
3) .O-CH2-CH2-N(CH3)2
c)
Chloroquine
4) .NH-C6H3(OH)CH2(C2H5)2
d)
Diphenhydramine
e) Chlorpromazine
Q.6 The following forms under Schedule A of
the Drug and Cosmetic Act are utilized for
applying for licenses listed a to e. Match
them correctly
1) Form 8 a) Application to Import
drugs for personal use
2) Form 12 A b) Application for grant of
license to sell, stock or distribute the drug
3) Form 19 c) Application to import biological
products
4) Form 24 C d) Application to manufacture
homeopathy drugs
e)
Application to import drugs for research purposes
Q.7 Listed below are the instruments used for
measuring the factors given in a to e.
1) Rotational viscometers a) Shear rate/shear stress & viscosity
2) Penetrometers b) Melting
point
3) Hansen-paddle equipment c) For consistency and hardness of
relatively rigid semisolids
4) Glass electrode d) Dissolution
of granules and tablets
e) pH indicating electrode
Q.8 Symptoms of the following diseases are
indicated from a to e. Match them correctly.
1) Cushing’s syndrome a) Hyperthyroidism
2) Addison’s disease b) Inflammatory bowel
3) Grave’s disease c) Primary adrenal
insufficiency
4) Crohn’s disease d) Decreased production of
Cortisol
e) Increased production of Cortisol
Q.9 Some possible causes are mentioned in a
to e for the following defects during the
film coating of tablet. Match them correctly.
1) Chipping a) Poor spreading of sprayed droplets
2) Cracking b) Over heating during spraying
3) Orange peel c) High internal stress in film
4) Blistering d) Excessive coating
process
e)
Precipitation of polymer due to high temperature or poor solvent
Q.10 Match the biological activity listed a
to e for the following drugs:
1) O-2-naphthyl-m, N-dimethyl thiocarbamate a)
Antineoplastic
2)
Trans-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-theinyl)vinyl]pyrimidine b) Anthelmintic
3) 2, 4-diamino-5(p-chlorophenyl)
]-6-ethylpyrimidine c) Antimalarial
4) p-di-2-chloroethyl) amino phenyl butyric
acid
d) Antifungal
e) Hypnotic/sedative
Q.11 Match the following method of
sterilization listed a to e for the following drugs:
1) Tetracycline injection a) sterilized by dry heat
2) Insulin injection b) Sterilized by
heating with bactericide
3) Quinine injection c) Sterilized by
bacterial filtration
4) Morphine injection d) Prepared by
aseptic method
e) Sterilized by heating in autoclave
Q.12 Given below are the receptors and their
antagonists. Match them correctly.
1) GABA receptor a) Buprenorphine
2) Histamine-H2-receptor b) Diazepam
3) Opiate receptor c) Ranitidine
4) β-adrenergic receptor d) Nifedipine
e) Atenolol
Q.13 The names of equation for various
expressions are given below. Match them correctly
1) Id = 607nCD1/2m2/3t1/6
a) Mark -
Houwink
2) V = πr4tΔP/8l.n. b)
Ilkovic
3) [n] = kMα c)
Poiseuille
4) Tz = (0.5 - 0.67) Tm d) Boyer-Beaman
e) Beer-Lambert
Q.14 Various equations are used for size
reduction of materials of different nature.
1) Rod mill a) Sticky material
2) Fluid energy mill b) Abrasive material
3) Cutting mill c) Thermo labile
material
4) Revolving mill d) Fibrous material
e) Thermo stable material
Q.15 Match the drugs in a to e which inhibit
the following enzymes.
1) Carbonic anhydrase a) Dicloxacillin
2) Dihydrofolate synthetase b) Physiostigmine
3) β-lactamase c) Acetazolamide
4) Acetylcholinestrase d)
Sulphonamide
e)
Ibuprofen
Q.16 Given below are some important drugs.
Appropriate tests are listed (a to e) . Match
them correctly
1) cardiac glycosides a) p-dimethylamino
benzaldehyde
2) Ergot alkaloids b) Fluorescence with
dilute H2SO4
3) Quinoline sulphate c) Leibermann Buchard test
4) Camphor d) 2,
4-dinitrophenyl hydrazine
e) Benedict’s test
Q.17 The undesirable effects of antibiotics
are listed in a to e. Match them correctly.
1) Tetracycline a) Gray baby syndrome
2) Streptomycin b) Discolouration of teeth
3) Chloramphenicol c) Jaundice
4) Rifampicin d) Obesity
e) Ototoxicity
Q.18 Choose the most appropriate starting
material listed a to e for the synthesis of the
following drugs
1) Riboflavin a) p-anisidine
2) Progesterone b) 3, 4-dimethylaniline and
D-ribose
3) Isoniazid c) Diasogenin
4) Indomethacin d) γ-picoline
e)
Lumiflavine
Q.19 Absorption frequencies (cm-1)
spectroscopy for carbonyl groups are given (a to e).
1) .COCl a) 1720
2) .O-CO-O- b) 1735
3) .CHO c) 1750
4) .CONH2 d) 1776
e) 1812
Q.20 Following are the prefixes used in
nomenclature which signifies as indicated from a to e.
1) Levo a) Not all the
same atoms
2) Ortho b) Rotates the plain of polarized light to the
left
3) Poly c) Identical
molecules
4)Hetero d) Signifies the 1,
2-positions in the benzene ring
e)
Threo-configuration
Answer
Key-1990 (Multiple Choice)
1.c 2.a 3.b 4.b 5.d 6.a 7.c 8.a 9.c 10.a 11.d
12.a 13.b 14.c 15.b 16.c 17.d 18.c 19.b 20.c 21.a 22.d 23.d 24.c 25.b 26.c 27.a
28.a 29.b 30.b 31.c 32.b 33.a 34.c 35.d 36.a 37.b 38.b 39.b 40.b
Match
the column
1. (1) a (2) b (3) c (4) d 2. (1) e (2) b (3) c (4) a
3. (1) c (2) e (3) d (4) b 4. (1) e (2) c (3) d (4) b
5. (1) c (2) b (3) d (4) a 6.
(1) c (2) a (3) b (4) d
7. (1) a (2) c (3) d (4) e 8.
(1) e (2) c (3) a (4) b
9. (1) d (2) c (3) a (4) b 10.
(1) d (2) b (3) c (4) a
11. (1) d (2) c (3) e (4) b 12. (1) b (2) c (3) a (4) e
13. (1) b (2) c (3) a (4) d 14. (1) a (2) c (3) d (4) b
15. (1) c (2) d (3) a (4) b 16. (1) c (2) a (3) b (4) d
17. (1) b (2) e (3) a (4) c 18. (1) b (2) c (3) d (4) a
19. (1) d (2) e (3) b (4) a 20.
(1) b (2) d (3) c (4) a
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