Choose the correct answers.
Q.1 Cortisone is
a) 4-Pregnan-12α, 21-diol-3, 20- di-one b) 4-Pregnen-17α, 21-diol-3, 11,
20- tri-one
c) 4-Pregnan-16α, 21-diol-3, 20- di-one d) 4-Pregnan-17α, 21-diol-3, 11, 20- tri-one
Q.2 Pregnenolone and intermediate in the
synthesis of steroids on oppeneur oxidation gives
a) Progesterone b) 9α-Fluorocortisol c) Triamicinolone d) α-methyl prednisolone
Q.3 In congestive cardiac failure, digitalis
glycosides are used because it increase
a) the heart rate b)
the force of myocardial contraction
c) the venous pressure d) the cardiac
filling pressure
Q.4 Shrinkage of gel by extrusion of liquid
is called
a) Synersis b) Dilatancy c) Plasticity d) Ebullition
Q.5 The sweetening agent commonly used in
chewable tablet formula is
a) Sucrose b) Cyclamate sodium ) Saccharin sodium d) Mannitol
Q.6 Carbamazepine is tricyclic
antidepressant. It is classified as
a) Benzodiazepine b) Arylalkanolamine c) Immunnostilbene d) Benzimidazole
Q.7 Sulfa drugs can be conveniently estimated
using the reagent.
a) 4, 4’-Dithio bis-(2-nitrobenzoic acid) b) Tris-(hydroxy methyl)-amino methane
c) N-(1-naphthyl) Ethylenediamine d) N-ethylmaleimide
Q.8 Testosterone can be commercially
synthesized from
a) Sarasaspogenin b) Mexogenin c) Oubagenin d) Halotensin
Q.9 Ehrlich’s reagent is
a) Bismuth iodide solution b)
p-dimethyl aniline solution in methanol
c) p-dimethyl amino benzaldehyde solution d) p-dimethyl aniline solution in
ethanol
Q.10 The neurotransmitter released at the end
of the sympathetic nerve fibre is
a) Epinephrine b) nor-epinephrine c) Acetylcholine d) Physiostigmine
Q.11 The dose of a drug is 5 mg per kg body
weight. How much of the drug is required
for a boy of 12 year who’s weight 21 kg?
a) 0.5 mg b) 1.0 mg c) 1.5 mg d) 2.0 mg
Q.12 Rancidity of a fat is due to
a) Oxidation b) Saponification c) Hydrolysis d) Neutralization
Q.13 Resolution of a Monochromator is the
ability to distinguish
a) As separate entities adjacent spectral
features b) Separation of different colours
c) Separation of UV light and visible light d) Dispersing
characteristics.
Q.14 Important activities noticed in
Testosterone
a) Androgenic, Myotropic and anabolic b) Progesterone, Myotropic and anabolic
c) Estrogenic, Mitotic and anabolic d) Androgenic, Optometric and Katabolic
Q.15 Fruits which are derived from the plants
umbelliferae are all of the type
a) Cremocarp b) Pericarp c) Epicarp d) Mesocarp
Q.16 Amygdaline on hydrolysis gives
a) Mandelonitrile + Benzaldehyde b) Mandelonitrile +
Benzaldehyde + Glucose
c) Mandelonitrile + Glucose d) Mandelonitrile +
Benzaldehyde + Rhamanose
Q.17 Erythromycin is an antibiotic. It
belongs to the class of
a) β-lactam b) Aminoglycoside c) Macrolide d) Peptide
Q.18 Vinblastine and Vincristine act by
a) Interfering with the synthesis of transfer
RNA b) Inhibiting the
fragmentation of DNA
c) Binding to protein d)
Incorporating into folic acid metabolism
Q.19 Water attack test is used to identify
the alkalinity in
a) Type I glass b) Type II glass c) Type III glass d) All of these type
Q.20 Select the drug that will aggravate
bronchial asthma
a) Amphetamine b) Morphine c) Propranolol d) Tubocurarine
Q.21The presence of impaired electron in
metal ion complex meant for spectral analysis is called
a) Paramagnetic b) Diamagnetic c) Bimagnetic d) Unimagnetic
Q.22 The biological half life of a drug
a) is a constant physical property of the
drug b) is a constant chemical
property of the drug c) may be increased in patient with renal impaired
function.
d) may be decreased in patient with renal
impaired function.
Q.23 The Ilkovic equation in the
polarographic measurement is given by
a) V = πr4tΔP/8l.n. b) Id
= 607nCD½m⅔t1/6 c) V = H2R2/2 . e/m
d) P0 – P =(1-e-abc)
Q.24 The vitamin has deodorant property
a) Vitamin A b) Vitamin C c) Vitamin D d) Vitamin E
Q.25 A type of flow in which viscosity
increases when the substance is agitated is
a) Plastic b) Pseudo plastic c) Dilatant d) Thixotropic
Q.26 Sub-coating is given to the tablets
a) to increase the bulkiness b) to avoid
deterioration due to microbial attack
c) to prevent the solubility in acid medium d) to avoid stickiness
Q.27 Water resistance of glass containers are
tested by measuring
a) amount of alkali released into water b) amount of acid released into
water
c) estimation of silicate d)
turbidity
Q.28 the pH of a pharmaceutical buffer system
can be calculated by
a) pH partition theory b) Noyes Whitney law
c) Henderson Hasselbalch equation d) Michaelis Menten
equation
Q.29 Chlorambucil is an anticancer drug its
structure is
Q.30 The stationary phase
in thin layer chromatography is
a) Adsorbent
b) Liquid held between glass
plate and adsorbent c) Glass
plate d) none of these
Q.31 Digoxin
a) has its action
terminate metabolism in liver b) has plasma
t1/2 of 6 hours
c) should be given
half of its normal dose to hypothyroid patient
d) provides
benefit in atrial fibrillation increasing the force of contraction
Q.32 The ingredients
mentioned below are commonly used as the coating agent for film coating except
a) Cellulose acetate
phthalate b) carnauba
wax
c) Hydroxy
ethyl cellulose d)
sodium carboxy methyl cellulose
Q.33 Morphine is drug of
choice for
a) Urinary
tract infection b) Colic pain
c) Bronchial asthma d) Cardiac asthma
Q.34 Drugs used in the
treatment of bronchial asthma usually
a) Block both α and
β-adrenergic receptors b)
stimulate α-receptor but block β- receptor
c) Stimulate
β-receptor but block α-receptors d) Stimulate α and
β-receptors
Q.35 The formula for the
preparation of Ascorbic acid injection I.P. may include
a) Glacial acetic acid
b) Dilute hydrochloric
acid c) Propylene
glycol
d) sodium
carbonate or sodium bicarbonate or sodium hydroxide in water
Q.36 The chemical
reaction shown below can be carried out by using the reagent listed
from a to e. indicate the correct one.
a) CH3MgBr b) CuCl2 c) AlCl3 d) CH3COONa
Q.37 Lactose is most widely used diluent in
the tablet formulation. However, it is not
used in the formulation of one of the
following:
a) Pyrazinamide b) Ibuprofen c) Sulphacetamide d) Isoniazid
Q.38 The area under serum concentration time
curve of drug represents
a) The biological half life of the drug b) The amount of drug in the
original dosage form
c) The amount of drug absorbed d) The amount of drug
excreted in the urine.
Q.39 Vinca alkaloids are isolated from:
a) Catharanthus roseus and contain indole and
indoline moieties.
b)
Roseochromogens and contain indole and indoline moieties
c) Catharanthus roseus and contain quinoline
and Quinaldine
d) Catharanthus indicus and contain quinoline
& Indole
Q.40 Aprotic solvents have
a) Acidic properties b)
Basic properties
c) Both Acidic properties and Basic properties
d) No Acidic or Basic properties
Match
the followings
Q.1 The antibiotics and their adverse effects
are mentioned below. Match them correctly.
i) Chlormphenicol a) Haemolytic anaemia
ii) Erythromycin b) Hepatotoxicity
iii) Cephalosporin c) CNS toxicity
iv) Streptomycin d) Nephrotoxicity
e) Ototoxicity
Q.2 Permitted limits of ethylene oxide in
various products are mentioned below.
Match them correctly.
i) Ophthalmic preparations a) 5 ppm
ii) Hard gelatin capsule shells b) 10 ppm
iii) Surgical material c) 15 ppm
e) 35 ppm
Q.3 Expressions for the following terms are
given below in a to e. Match them correctly.
i) Beer’s law a) T = I/I0
ii) Absorptivity b) log I0/I = abc
iii) Transmission c) A = log (1/T)
iv) Absorbance d) a = bc
e) Iab = I0
(1 – e-2.3 abc)
Q.4 The side chains as given from (i) to (iv)
is present in local anaesthetics listed a to e..
Match them correctly.
i) COO-CH2-CH2-N(C2H5)2
a) Procaine
ii) COO-CH2-CH3 b)
Lidocaine
iii) COO-CH2-CH2-CH2-CH3
c) Benzocaine
iv) NH-CO-CH2-N(C2H5)2
d) Butamben
e) Dibucaine
Q.5 Match the suitable test organisms for
assaying the antibiotics mentioned below.
i) Doxycycline a) Bacillus cereus
ii) Rifampicin b) Bacillus pumilus
iii) Erythromycin c) Staphylococcus saprophyticus
iv) Tetracycline d) Bacillus subtilis
e)
Micrococcus luteus
Q.6 The region of spectrum for the following
are the given in terms of wavelength (cm)
in a to e. Match them correctly.
i) X-rays a) 10-6 – 10-5
ii) UV- rays b) 10-5 – 10-4
iii) Visible- rays c) 10-8 – 10-6
iv) Infra red rays d) 10-4 – 10-2
e) 10-2
– 10
Q.7 The causative organism of disease is given
and the drug used for the treatment is
indicated in a to e. Match them correctly.
i) E. histolytica a) Clofazimine
ii) P. falciparum b) Chlormphenicol
iii) S. typhi c) Emetine
iv) M. leprae d) Pyremethamine
e) Mebendazole
Q.8 Match the correct mechanism of action for
the diuretic agents mentioned below..
i) Acetazolamide a) Increase serum K+ level
ii) Chlorthalidone b) Competitively antagonizes Aldosterone
iii) Spironolactone c) Inhibits active Na+ secretion,
decreasing K+ excretion in distal nephron
iv) Triamterene d) Inhibits carbonic anhydrase
e)
inhibits electrolyte reabsorption in the distal portion of the ascending
limb
of the loop of Henle
Q.9 The position 5 of barbituric acid is
mentioned below have substituents as indicated in
a to e. Match them properly to identify
correct structure. R1 R2
i) Phenobarbital a) –C2H5,
-C2H5
ii) Barbital b) –C2H5,
-CH(CH3)2
iii) Probarbital c) –C2H5, –C6H5
iv) Pentobarbital d) –C2H5, -CH(CH3)-C3H7
e)
–CH3, –C6H5
Q.10 Following drugs can be prepared starting
from the intermediates given in a to e.
Match them appropriately.
i) Atenolol a) 4-OH pheylacetamide
ii) Ibuprofen b) γ-picoline
iii) Haloperidol c) 4-NH2 quinoline
iv) Isoniazid d) Isobutyl benzene
e)
4-(p-chlorophenyl-4-OH piperidine
Q.11 Choose the most appropriate
instrument/apparatus listed from a to e for the study of
the following:
i) Thiamine a)
Calorimeter
ii) Ferrous ions b) pH meter
iii) Acidity of carboxylic acid c) Fluorimeter
iv) Barium sulphate d)
Coulorimeter
e) Nephalometer
Q.12 Following drugs are tested with reagents
listed in a to e. Match them correctly.
i) Aspartic acid a) α-naphthol in alcohol
ii) Dextran b) 2, 6-dichlorophenol
indophenol
iii) Nicotine c) Ninhydrin
iv) Vitamin A d) Antimony trichloride in
chloroform
e)
Potassium Bismuth Iodide solution
Q.13 Match the antibiotics to their mechanism
of action correctly:
i) Ampicillin a) Inhibition of
nucleic acid synthesis
ii) Chlormphenicol b) Inhibition of cell wall
synthesis
iii) Nystatin c) Inhibition of
growth by competitive antagonism
iv) Rifampicin d) Inhibition of protein
synthesis
e) Inhibition of cell membrane function
Q.14 As per Drugs and Cosmetic Act, Match the
correct Schedules to their corresponding titles.
i) Schedule P a) Standards for poisons
ii) Schedule Q b) Standards for cosmetics
iii) Schedule S c) Standards for
Ophthalmic preparations
iv) Schedule FF d) Life period of drugs
e) Coal-tar colours used in
cosmetics
Q.15 The sources and constituents of the
following umbelliferous fruits are listed in a to
e. Match them correctly.
i) Caraway a) Foeniculum vulgare-Anthole/Fenchone
ii) Fennel
b) Carum carvi-Carvone
iii) Dill c) Anethum
graveolens-carvone
iv) Coriander d) Cuminuim
cyminum-cuminic aldehyde
e)
Coriandrum sativum- Linalool
Q.16 Given below are some of the
microscopical diagnostic features of the drugs listed in
a to e. Choose the appropriate one:
i) Cluster crystals of calcium oxalate a) Stramonium leaves
ii) Candelabra trichomes b) Cinnamon Bark
iii) Phloem fibres c)
Alexandrian senna
iv) Glandular trichomes d) Digitalis
leaves
e) Verbascum thapsus
Q.17 In the preparation of capsule shell, the
ingredients mentioned are present for
specific purpose. Match them correctly.
i) Preservatives a) Mineral oil
ii) Acid solubility b)
Essential oil
iii) Organoleptic addatives c) Titanium dioxide
iv) Opacifier d) Fumeric
acid
e) Propyl paraben
Q.18 The emulgents and their sources are
given below. Match them correctly.
i) Karaya a) Synthetic
ii) Carageenan b) Collagen
iii) Guar c) Sea weed
iv) Gelatin d) Gum exudates
e)
Seed extract
Q.19 Listed below are some schedules (i) to
(iv) and rules a to e. Match them correctly.
i) C a) List of medicine
required to be taken only under supervision of R.M.P.
ii) F b) Biological and special products
iii) G c) Provision applicable to Vaccines, Toxins,
Antigens and Sera
iv) M d) GMP requirements of
factory premises, plant equipments etc.
e) standards for surgical
dressings.
Q.20 Preparations listed (i) to (iv) are
assayed by the method given in a to e. Match them
correctly.
i) Heparin Sodium Injection I.P. a)
Biological assay using prostate gland of immature rats
ii) Gentamycin Injection I.P. b)
Biological assay using Clostridium WelchiType A antitoxin
iii) Mixed Gas-gangrene Antitoxin I.P. c) Microbiological assay
using method a
iv) Chorionic Gondotropin Injection I.P. d) Biological assay using Sheep
plasma
e) Biological assay using human plasma
Answer
Key-1991 (Multiple Choice)
1.b 2.a 3.b 4.b 5.d 6.c 7.c 8.a 9.c 10.b 11.c
12.a 13.a 14.a 15.a 16.c 17.c 18.b 19.b 20.c 21.a 22.c 23.b 24.d 25.c 26.a 27.a
28.c 29.c 30.a 31.d 32.b 33.b 34.c 35.d
36.c 37.d 38.c 39.a 40.d
Match
the column
1. (1) a (2) b (3) d (4) e 2. (1) a (2) d (3) c (4) b
5. (1) c (2) d (3) e (4) a 6. (1) c (2) a (3) b (4) d
7. (1) c (2) d (3) b (4) a 8. (1) d (2) e (3) b (4) c
9. (1) c (2) a (3) b (4) d 10. (1) a (2) d (3) e (4) b
11. (1) c (2) d (3) b (4) e 12. (1) c (2) a (3) e (4) d
13. (1) b (2) d (3) e (4) a 14. (1) d (2) e (3) b (4) c
15. (1) b (2) a (3) c (4) e 16. (1) c (2) e (3) b (4) d
17. (1) e (2) d (3) b (4) c 18. (1) d (2) c (3) e (4) b
19. (1) b (2) c (3) a (4) d 20. (1) d (2) c (3) b (4) a
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