Choose
the correct answers.
Q.1 Simethicone is a component of several
antacid formulations.
a) Wax b) Fat c) Aldehyde d) Silicone
Q.2 The Pharmacy Council of India is
constituted by the
a) Central Government b) State Government c) Parliament d) Legislative Assembly
Q.3 All of the following physicochemical
constants are useful in predicting the solubility of a drug except
a) Dielectric constants b) pH of a solution c) pKa of the drug d) valency
Q.4 Sigma blade mixers are commonly used in
a) Wet granulation b) Dry granulation c)
powder mixing d) Crude fibre
mixing
Q.5 The 5β pregnane is said to have a
a) trans-anti-trans-anti-trans back bone b) cis-anti-trans-anti-trans back bone
c) cis-syn-trans-syn-trans back bone d)
trans-anti-cis-anti-cis back bone
Q.6 Many drugs are chiral. In the synthesis
of chiral drug molecule in symmetric environment.
a) Always one enantiomer obtained b) Always both enantiomers obtained in
equalamounts
c) Always both enantiomers obtained in
unequal amounts d) none of
these
Q.7 Poorly manufactured tablets may have
small pin holes on the surface. This phenomenon is
known as
a) Picking b) Mottling c) Leaching d) Cracking
Q.8 Ascorbic acid exist in nature
a) only in the reduced form which has only
biological activity
b) only in the oxidized form which has only
biological activity
c) in both reduced and the oxidized form in the
state of reversible equilibrium which has biological activity d) none of the above
Q.9 In the stable conformation of 5α-pregnane
a) Ring A, B and C are in boat confirmation
b) Rings A and B are in boat while C in chair
conformation
c)
Ring A is in boat while B and C in chair conformation
d) All the three rings chair conformation.
Q.10 Among the following Preparation which
one will be the most irritating to the eye?
a) Purified water b) 0.7% NaCl solution c) 0.9% NaCl d) 1% NaCl solution
Q.11 In case of hypothyroidism, the preferred
thyroid preparation is
a) Levothyroxine b) Dextrothyroxine c)
Liothyronine d) none of these
Q.12 D- Fructose on simple reduction gives
a) only Mannitol b) only Sorbitol c) L – fructose d) mixture of Mannitol and Sorbitol
Q.13 Lugol’s solution contains 5% of iodine.
How much of Lugol’s solution is administered to a
patient thrice daily to provide 60 mg of
iodine daily?
a) 0.2 ml b) 0.3 ml c) 0.4 ml d) 0.5 ml
Q.14 The anticoagulant Heparin is obtained
from
a) Sheep’s lung b) Dog’s kidney c) Rabbit’s heart d) Rat’s uterus
Q.15 Which one of the following types of
adverse drug reactions are not believed to be dose
related phenomenon?
a) Side effects and reactions b) Toxic reactions and hypersensitivity
c) Side effects and hypersensitivity d) Hypersensitivity and
idiosyncrasy.
Q.16 The structure of a drug having an
symmetric centre is
using IUPAC system, the configuration will be
will be
a) R b) S c) α d) β
Q.17 Cryoscopic method is similar in the
calculation of isotonic solutions. This is based on
a) freezing point depression of the drug b) molecular concentration of the
drug
c) pH of the drug d)
none of the above
Q.18 one thousand nano gram equals to one
a) Centigram b) Gram c) Kilogram d) Microgram
Q.19 Biological role of thiamine is because
of facile formation
a) Thiamine hydrochloride b) Pyrophosphate ‘ylid’ c) Thiamine sulphate d) None of these
Q.20 Infected blood products may produce
serum hepatitis due to presence of
a) Hepatitis A virus b) Hepatitis B virus c) Hepatitis C virus d) None of these
Q.21 pH of a buffer system can be calculated
by using
a) pH partition b) Noyes – Whitney law c) Henderson-Hesselbalch equation d) None of these
Q.22 Osmolality measures the total number of
particles dissolved in a …….of water and
depends on the electrolytic nature of the
solute
a) Kilogram b) kilolitre c) litre d) specified quality
Q.23 Ergot is the sclerotium of
a) fungus claviceps purpurea b) fungus claviceps notatum
c) strychnose mixotatorum d) fungus
penicillium chrysogenum
Q.24 A highly selective semiquantitave method
of detecting microbial antigen in biological fluid
is done by
a) Radio immunoelectrophoresis b) Counter
immunoelectrophoresis
c) HPLC
d) Freeze dried centrifugal method
Q.25 the glass electrode used in pH
measurement is
a) metal-metal oxide electrode b) a membrane electrode
c) Ion selective electrode d) none of the
above
Q.26 In phenothiazine tranquillizing agents,
replacement of C-2 hydrogen with chlorine
a) Decrease the activity b) Increase the activity
c) Activity unaffected d)
leads to decrease penetration in CNS
Q.27 The loading dose of a drug is based upon
the
a) time taken for complete elimination b) percentage of drug excreted
unchanged in urine
c) percentage of drug bound to plasma protein
d) apparent volume of distribution
and the
desired drug concentration in plasma
Q.28 Conformation of drugs are commonly
determined by
a) NMR b) NMI c) Mass spectrometry d) pH determination
Q.29 Aminophylline solutions on exposure to
air may develop
a) crystals of theophylline b) Precipitate
of Aminophylline
c)
Precipitate of ethylene diamine d) straw colour
Q.30The hypotensive
effect of Clonidine is due to its action on
a) β-adrenergic
receptor b) α-adrenergic receptor c) H2-receptor d)
H1-receptor
Q.31 A step in vitamin A synthesis is
The product obtained will be
a) 3-hydroxy-3-methyl-1-pentene-4-yne b) hex-1-yne-one
c) 3-amino-3-methyl-1-pentene-4-yne d) none of the above
Q.32 Sodium nitropruside is one of the most
potent blood pressure lower drug. Its use is
limited because of
a) Its short duration of action b) Very
long duration of action
c) Inactive in oral route d)
none of these
Q.33 Cocaine is monoacid tertiary base on
treatment with dilute acids
a) Ecgonine, methyl alcohol and scopic acid b) Ecgonine, methyl alcohol and cinnamic
acid
c) Ecgonine, methyl alcohol and benzoic acid d) Ecgonine, ethyl alcohol and benzoic acid
Q.34 Use of Isoniazid is restricted due to
a) Ototoxity b) Hepatotoxicity c) Neurotoxicity d) Bone marrow depression
Q.35 Diosgenin is
a) an alkaloid obtained form dioscorea b) a carbohydrate obtained from
dioscorea
c) a glycoside obtained from dioscorea d) none of these
Q.36 The IUPAC nomenclature of the sulindac
analogue
a) (Z)-Fluoro-2methyl-1-(p-methyl sulfinyl) phenylmethylene-1H-indene-3-acetic
acid
b) (E)-Fluoro-2methyl-1-(p-methyl sulfinyl) phenylmethylene-1H-indene-3-acetic
acid
c)
(R)-Fluoro-2methyl-1-phenylmethylene-1H-indene-3-acetic acid
d) (S)-Fluoro-2methyl-1-(p-methyl sulfinyl) phenylmethylene-1H-indene-3-acetic
acid
Q.37 Bubble point test is done to determine
a) the surface tension of the liquid in
capillary tube b) the viscosity of
the liquid in ampoules
c) the pH of 1 % solution d) the volume of the
solution stored in a specified container
Q.38 The “Hemiacetal” form of aldosterone is
between
a) C-11β-hydroxy and C-20 Carbonyl b) C-11β-hydroxy and C-21
Carbonyl
c) C-11β-hydroxy and C-18 Carbonyl d) C-21β-hydroxy and C-20 Carbonyl
Q.39 Surfactants are characterized by the
presence of
a) water solubilizing and fat solubilizing
group in the same molecule
b) Only negative charges c) Only positive charges d) none of these
Q.40 Acetous perchloric acid solution a
common titrant in non-aqueous titrimetry is standardized
a) Standard alcoholic KOH solution b) N/10 Potassium permanganate
c) Potassium hydrogen phthalate solution in
glacial acetic acid
d) Mercuric acetate in glacial acetic acid
Match
the followings
Q.1 The antibiotics mentioned below are
obtained from the organisms listed from a to e.Match
them correctly
i) Neomycin a) Streptomyces fradiae
ii) Gentamycin b) Micromonospora purpurea
iii) Bacitracin c) Streptomyces tenebrarius
iv) Tobramycin d) Bacillus subtilis
e)
Bacillus polymyxa
Q.2 Given below a list of medicinal plants.
Match them correctly with list of constituents given
i) Holarrhena antidysentrica a) Conesecine
ii) Cymbopogen flexuosus b) Citral
iii) Urginea indica c) Mucilage
iv) Linum usitatissimum d) Cocaine
e) Scillarenin
Q.3 The following drugs are included under
the schedules listed a to e. Match them correctly
i) Meprobamate a) Schedule E
ii) Poisonous drugs b) Schedule
FF
iii) Ophthalmic preparations c) Schedule C and C1
iv) Biological and special product d) Schedule X
e)
Schedule O
Q.4 Following drugs contain two hydroxyl
groups each. Nature of these hydroxyl group are
indicated in a to e. Match them correctly.
i) Morphine a) Alcoholic
but 10 and 20
ii) Chloramphenicol b) Alcoholic and both10
iii) Apomorphine c) Both phenolic
iv) Cortisone d) one alcoholic
and one phenolic
e) Both alcoholic but one 10 and one 30
Q.5 The following molecules contain
heterocyclic rings listed in a to e. Match them
i) Haloperidol a) Pyrimidine
ii) Sulphadiazine b) Pyridine
iii) Amiloride c) Piperidine
iv) Pheniramine d) Pyrazine
e) Pyridazine
Q.6 Following drugs exhibit their action by
enzymes inhibition. Enzymes are listed in a to e. Match them correctly.
i) Capopril a)
β-lactmase
ii) Clavulanic acid b) MAO
iii) Pargyline c)
Mono-oxygenase
iv) Methazolamide d) Carbonic Anhydrase
e) ACE
Q.7 Following preparations are assayed by
biological techniques using the animal or its
parts listed in a to e. Match them correctly.
i) Cod liver oil a) Sheep blood
ii) Heparin injection b) Rabbit
iii) Oxytoxin injection c) Rat
iv) Insulin injection d) Anaesthetized chicken
e) Cat
Q.8 Following I.P. assayed involved the
principle listed in a to e. Match them
i) Sodium chloride a) Titration with N/10 iodine
ii) Trimethoprim b) Oxidation involving
2,6-dichlorophenol Indophenols
iii) Analgin tablet c) Argentometry
iv) Ascorbic acid powder d)
Non-aqueous acidimetry
e) Acidimetry
Q.9 Given below are some anti-hypertensive
mechanisms. Drugs which are closely
associated with these mechanisms of action
are listed in a to e. Match then correctly.
i) Ganglion blocking agent a) methyl dopa
ii) Catechlolamine depletory b) Hydralazine
iii) False neurotransmitter c) Reserpine
iv) Direct action arterioles d)
Mecamylamine
e) Veratrum alkaoids
Q.10 Listed are vitamins. Their association
with certain co-enzymes is well known. The
names of co-enzymes are given in a to e.
Match them correctly.
i) Thiamine a) Co-carboxylase
ii) Riboflavin b) Co-enzyme A
iii) Pantothenic acid c) NAD
iv) Nicotinamide d) FAD
e)
ATP
Q.11 Listed are some of the crude drugs which
are tested for the active constituents by
the mentioned in a to e. Match them
correctly.
i) Cinchona Bark a)
Fluorescence
ii) Nux Vomica seeds b) Keller Killiani
iii) Digitalis leaves c) Bontrager’s
test
iv) Senna leaves d) Mayer’s
test
e) Sham’s test
Q.12 Listed are some of the common volatile
oils. Their active constituents are given in a
to e. Match them correctly.
i) Pappermint oil a) (+) Limonine
ii) Turpentine oil b) 1, 8 – Cineole
iii) Eucalyptus oil c) α pienine
iv) Lemon oil d) (-) Methanol
e) (+) Methanol
Q.13 Match the each pair with the type the
type of structural relationship they exhibit.
i) (R) and (S) Naproxen a)
Tautomers of one another
ii) Dilactim and Monolactam form of
barbituric acid b)
Diasteomers of one another
iii) Quinine and quinidine c) None- Superimposible
mirror images of each other
iv) Eclipsed and staggered form of
phenothiazine about side chair carbon-carbon bond
d) Superimposible mirror images of each other
e) Conformational isomer of each other
Q.14 Various polymers used in pharmacy are
given below. Match with the respective monomers
i) Carbopol a) Methacrylate ester
ii) Eudragit b) Ethylene
iii) Polyethylene c) Ethylene glycol
iv) Polycarbarnate d) (Bis-phenol + Phospgene)
e) Acrylic acid
Q.15 Following are some naturally occurring
substances. They are classified under
different categories with listed in a to e.
Match them correctly.
i) Prostaglandins a) Opioids
ii) Codeine b) Ecosinoids
iii) Angiotensin II c) Corticoids
iv) Stropanthidin d) Peptide
e) Cardinolide
Q.16 Following are some of the analytical
instruments. Their important components are
listed in a to e. Match them correctly.
i) HPLC a)
Monochromator
ii) IR double beam spectrophotometer b) Dropping mercury electrode
iii) Karl-Fisher titrator c) Isocratic pump
iv) Polarograph
d) Platinum electrode
e) Polarizer
Q.17 The hard gelatin capsule size are
mentioned in their number. Their approximate
capacity are listed in a to e. Match their
correct volume.(Lachman, 3rd edition page no-386)
i) 0 a) 0.10 ml
ii) 1 b) 0.15 ml
iii) 3 c) 0.30 ml
iv) 5 d) 0.55 ml
e) 0.75 ml
Q.18 Listed are some of the commonly used
drugs. Their pharmaceutical actions are
listed in a to e. Match them correctly.
i) Aspirin a) Rises
body temperature
ii) Acetaminophen b) Analgesic
anti-inflammatory
iii) Phenylbutazone c) Non-anti-inflammatory
analgesic
iv) Probenacid d) Increases depth of respiration
e) Increase fluid retention
Q.19 Match the preservatives/antioxidants
listed in a to e. Match preparations mentioned below.
i) Anaesthetic ether a) Chloroform
ii) Formaldehyde b) Ethylene diamine
iii) Injection of adrenaline c) Paraformaldehyde
iv) Aminophylline d) Sodium bisuphite
e) Alcohol
Q.20 In communation, certain type of
materials listed in a to e are not suitable for the
mills mentioned bellow. Match them
correctly.(Lachman, 3rd edition page no-38)
i) Cutter mill a) Soft material
ii) Hammer mill b) Adhesive material
iii) Revolving mill c) Friable material
iv) Fluid energy mill d) Liquefiable material
e) Abrasive material.
Answer
Key-1992 (Multiple Choice)
1.d 2.a 3.d 4.c 5.b 6.b 7.a 8.c 9.d 10.a 11.a
12.d 13.c 14.a 15.d 16.a 17.a 18.d 19.b 20.b 21.c 22.a 23.a 24.b 25.b 26.b 27.d
28.a 29.a 30.b 31.a 32.a 33.c 34.c 35.c 36.a 37.a 38.c 39.a 40.a
Match
the column
1. (1) a (2) b (3) d (4) c 2. (1) a (2) b (3) e (4) c
3. (1) d (2) a (3) b (4) c 4. (1) d (2) a (3) c
(4) e
5. (1) c (2) a (3) d (4) b 6. (1) e (2) a (3) b
(4) d
7. (1) d (2) a (3) c (4) b 8. (1) c (2) d (3) e
(4) a
9. (1) d (2) c (3) a (4) b 10. (1) a (2) d (3) b
(4) c
11. (1) a (2) d (3) b (4) c 12. (1) d (2) c (3) b
(4) a
13. (1) b (2) a (3) c (4) e 14. (1) e (2) a (3) b
(4) d
15. (1) b (2) a (3) d (4) e 16. (1) c (2) a (3) d
(4) b
17. (1) e (2) d (3) c (4) b 18. (1) d (2) c (3) b
(4) e
19. (1) e (2) c (3) d (4) b 20. (1) c (2) e (3) a
(4) b
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