1.Choose the correct answers.
Q.1 Triamicinolone is
a) 9α-Fluoro-16α-Hydroxyprednisolone
b) 9β- Fluoro-16α-Hydroxyprednisolone
c) 9α
-Fluoro-16β -Hydroxyprednisolone d) 9α
-Bromo-16α-Hydroxyprednisolone
Q.2 Surfactants are
characterized by the presence of
a) water solubilizing
groups alone b)
fat solubilizing groups alone
c) water
and fat solubilizing groups in same molecules d) groups with positive charge
Q.3 Gamma-globulin is
separated from serum by
a) agglutination
b) dialysis c) centrifugation d) salting out
Q.4 The stationary
phase in thin layer chromatography is
a) liquid
held between glass plate and silica gel b) silica gel c) glass plate d) none of the
above
Q.5 Benzoyl peroxide is
a) an
astringent b) an
emollient c) a
preservative d) a
keratolytic
Q.6 water for injection
differs from sterile distilled water as it is free from
a) carbon
di oxide b) pyrogens
c) preservatives
d) antioxidant
Q.7 The correct
equivalent for -100C is
a) -100F
b) +220F c) -180F d) +140F
Q.8 The active
metabolite of anti-cancer cyclophosphamide is
a) N-hydroxy
cyclophosphamide b) N-methyl
cyclophosphamide
c) 4-hydroxy
cyclophosphamide d) N-acetyl
cyclophosphamide
Q.9 Mebendazol, an
anthelmintic drug has one group at 5-position in the benzimidazole
structure.
It is
a) –S-
CH2-CH2-CH2-CH3 b) –S-Ph
c) Ph-SO2- d) Ph-COQ.
10 Sedative action of
barbiturates is due to substituents at C5. It is due to
a) high lipophilicity
of groups at C5 position b) electron
withdrawing effect
c) steric
effect d)
metal chelation
Q.11Monoamine oxidase
(MAO) inhibitors have serious side effects and toxicities. The
alternate
drugs of choice are
a) tricyclic
antidepressant b) hallucinogens c) amphetamines d) xanthine alkaloids
Q.12 Sterility test for
the materials meant for surgical suture requires incubation for
a) 7
days b) 14
days c) 21
days d) 20 days
Q.13 Silver-silver
chloride electrode consists of
a) silver wire coated
with calomel b) silver
wire coated with potassium chloride
c) silver
wire coated with silver chloride d) platinum wire coated with
silver chloride
Q.14 Extinction E =
a) log
I0/I b) log
T c) It/I0 d) I0.10-cl
Q.15 Senna leaf I.P. consists of
a) dried leaflets of Cassia acutifolia and
Cassia angustifolia
b) dried leaflets of Cassia indica c) dried
leaflets of Cassia carpinifolla
d) dried leaflets of Cassia carpinifolla and
Cassia acutifolia
Q.16 Conformational isomerism is
a) cis-trans isomerism b) optical isomer c) dextro-and
laevo-rotatory
d) non-identical spatial arrangement of atoms
in molecules resulting from rotation about one or more simple bonds.
Q.17 According to pH partition theory, a
wealthy acidic drug will most likely be
absorbed from the stomach because the drug
which exist, primarily in the
a) un-ionized, more lipid soluble form b) ionized, more water
soluble in acid media
c) form of weak acid and more soluble in acid
media
d) ionic form of the drug which facilitates
diffusion
Q.18 Blood flow through a capillary is
described by one of the following equations.
Choose the correct one.
a) Langmuir b) Noyes-Whitney c) Hildebrand d) Stokes
Q.19 Ionic mobility is denoted by
a) cm/sec b) degree Celcius/sec c) mg/sec d) none of these
Q.20 A mixture of hydrochloric acid and
acetic acid can be titrated satisfactorily by
a) potentiometry b) conductometry c) amperometry d) spectrophotometry
2.Match
the followings
Q.1 The drugs and their mechanisms of action
are listed below. Match them correctly.
i) Ca2+ channel blockers a)
Terbutaline
ii) β2-selective bronchodilator b) Diltiazem
iii) 5-HT antagonist c)
Ranitidine
iv) H2-receptor antagonist d)
Cyperoheptadine
e) Omeperazole
Q.2 The injections mentioned below are
usually sterilized by the process of a to e. Match
them correctly.
i) Hydrocortisone acetate inj. a) Sterilization by dry heat
ii) Morphine inj. b)
Sterilization by moist heat
iii) Paraldehyde inj. c) Sterilization by filtration
iv) Phenol and glycerin inj. d) Sterilization
by heating with bactericide
e) Aspetic operation
Q.3 The side chain structure for the following
drugs are given from a to e. Match them.
i) Primaquine
a) –O-CH2-CH(OH)-CH2-NHCH(CH3)2
ii) Chloroquine b) –CH2-CH2-CH2-N(CH3)2
iii) Propranolol c) –NH-(CH3)CH-(CH2)3-NH2
iv) Tinidazole d) –CH2-CH2-SO2-C2H5
e) –NH-(CH3)CH-(CH2)3-N(C2H5)2
Q.4 The drugs mentioned below are assayed by
the methods mentioned in a to e. Match
them correctly.
i) Sulphadiazine Tablets I.P. a) Non aqueous titration with 0.1N
perchloric acid using orcet
blue as
indicator.
ii) Salbutamol sulphate I.P. b) By measuring extinction at 444 nm
iii) Riboflavin tablets I.P. c) A dilute sulphuric acid
solution is titrated with 0.1 N
ceric ammonium sulphate using ferroin solution as indicator
iv) Ascorbic acid
tablet I.P d) Titrated
with 0.5 N NaOH using phenol red as indicator
e) Acidification with
HCl and with 0.1 M sodium nitrate
Q.5 The starting for
the synthesis of drugs 1 to 4 are mentioned from a to e. Match them.
i) Thyroxine a)
3-chloro acetyl phenol
ii) Phenylephrine b) 4-chloro
acetyl catechol
iii) Isoprenaline c)
Catechol
iv) Adrenaline d)
L-Tyrosine
e) resorcinol
Q.6 Following are test
organisms used for the I.P. microbiological assay of antibiotics.
Mach
them correctly.
i) Rifampicin a) Eschrechia
coli
ii) Tetracycline b) Klebsiella
pneumonia
iii) Streptomycin c) Micrococcus luteus
iv) Chloramphenicol d) Bacillus subtilis
e) Bacillus
cereus
Q.7 The following are
the test animals or substances used for the biological assay of
preparations
listed a to e. Match them correctly.
i) Mice a) Vasopressin
ii) Albeno rats b) Diphtheria
antitoxin
iii) Guinea pigs c) Insulin
iv) Sheep plasma d) Heparin sodium
e) Human
antihaemophyllic fraction
Q.8 The active form of
the enantiomer for the following drugs are given in a to e. Match
them
correctly.
i) Ibuprofen a) S-isomer
ii) Ephedrine b) D-isomer
iii) Propranolol c) cis-isomer
iv) Ethambutol d) L-isomer
e) R-isomer
Q.9 The ingredients
mentioned in a to e are used in various stages of sugar coating of
tablets.
Match them correctly.
i) Seal coating a) Gelatin
ii) Sub coating b) Carnauba wax
iii) Syrup coating c) Methanol
iv) Polishing d) PEG 4000
e)
Cane sugar
Q.10 The drugs a to e
are used as diuretics. Match them to their classes.
i) Osmotic diuretic a) Spironolactone
ii) Loop diuretics b) Isosorbide
iii) Potassium sparing
diuretics c) Merasalyl
theophylline
iv) Organomercurials
diuretics d) Furosemide
e) Probenecid
Q.11 Following bacteria are
classified based on their staining of antibiotics. Match them.
i) Clostridium
tetani a) Gram-positive cocci
ii) Eschrechia
coli b) Gram-positive bacilli
iii) Neisseria
gonorrhoeae c) gram-negative cocci
iv) Streptococcus
pyogenes d) Gram-negative
bacilli
e) Gram-positive cocci
Q.12 The following
prefixes are to identify the characteristic listed in a to e. Match them.
i) Hetero a) neighbouring
positions in the benzene ring
ii) Laevo b) rotates the polarized light to the
left
iii) Ortho c) several identical
molecules linked together
iv) Poly d) not all the same
atoms in the compound
e) Water is removed from the compound
Q.13 The following
Umbelliferous fruits are obtained from the plants mentioned in a to e.
Match
them correctly.
i) Anise a) Anethum
graveoleus
ii) Caraway b) Foeniculum vulgere
iii) Coriander c) Carum carvi
iv) Dill d) Pimpinella
anisum
e) coriandrum sativum
Q.14 The drugs listed
from (i) to (iv) are having the antihypertensive mechanism listed in
a
to e. Match them correctly.
i) Pindolol a) Vasodilator
ii) Minoxidil b) centrally acting
α2-adrenoreceptor agonist
iii) Captopril c) Diuretic
iv) Amiloride d) β-blocker
e) Angiotensin converting enzyme inhibitor
Q.15 A drug is deemed to
as indicated in (i) to (iv) and the corresponding definations are
given
in a to e. Match them correctly.
i) Misbranded drug a) It is marketed without
prescription
ii) Adulterant drug b) It is imported under
a name which belongs to another drug.
iii) Spurious drug c) It is not labeled
in the prescribed manner
iv) Drug abuse d) If it contains
any harmful or toxic substance
e)
If it develops addiction
3.
Fill in the blanks
a) Synthetic camphor
is optically…..1……and is prepared from…..2……whereas
natural camphor is optically… …3……..….and is obtained
from……..4……….
b) Alkaloids of ergot
exist in stereoisomeric pairs and they are derived from optically
isomeric
form. They are known as………5………..and……….6…………which
differ only in configuration at the asymmetric carbon atom
which carries..7….group.
c) In aseptic area,
the personnel are provided with uniforms made by……8…….or by
….9……
d) ….10…is used as
an….11…..indicator in….12……titrations, because the
fluorescence changes with….13……..
e) Polypropylene
glycol is usually included in topical formulations as a…14 &….15.
f) Transfer of most
drugs across biologic membrane occurs by…..16……diffusion
region…..17……concentration to one of
……18…….concentration.
g) Biologic half-life
of a that is eliminated by the first order kinetics is
mathematically represented by………….19………..
h) In Quillala bark, the dark patches often
found on the surface are known as….20….
Answer Key-1993 (Multiple Choice)
1.a 2.c 3.b 4.b 5.d 6.b 7.d 8.c 9.d 10.a 11.a 12.b
13.c 14.a 15.a 16.d 17.a 18.b
19.a 20.b
Match the column
1. (1) b (2) a (3) d (4) c 2. (1) e (2) d (3)
c (4) a
3. (1) e (2) b (3) a (4) d 4. (1) e (2) a (3)
b (4) c
5. (1) d (2) a (3) b (4) c 6. (1) d (2) e (3)
b (4) a
7. (1) c (2) a (3) b (4) d 8. (1) a (2) d (3) e (4) b
9. (1) d (2) a (3) e (4) b 10. (1) b (2) d (3)
a (4) c
11. (1) b (2) d (3) c (4) a 12. (1) d (2) b (3) a
(4) c
13. (1) d (2) c (3) e (4) a 14. (1) d (2) a (3)
e (4) c
15. (1) c (2) d (3) b (4) e
Fill in the blanks
A (1) Inactive (2)
α-pinene (3) active (4) Cinnamon camphor
B (1) Ergonovine (2)
ergotamine (3) carboxylic group in side the chain
C (1) Dacron (2)
tyvex
D (1) Alizarin (2) Pm
Indicator (3) complexometry (4) Complexation
E (1) humectant (2)
aqueous phase in hydrophilic ointment
F (1) Passive
diffusion (2) high concentration (3) Low
G (1) 0.693/k
H (1) rhytidom
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