1.Choose the correct answers.
Q.1 Natural camphor is
a) an optically inactive Aldehyde obtained from
Cinnamomum camphora
b) a white dextrorotatory ketone obtained from the
wood of Cinnamonum camphora
c) a white optically inactive ketone obtained from
the bark of Cinnamomum camphora
d) a white volatile Aldehyde
obtained from the bark of Cinnamomum camphora
Q.2 Ingredients used for capsulation in soft capsule
should flow by gravity at a
temperature not exceeding:
a) 350C b) 300C c) 250C d) 200C
Q.3 The region of the electromagnetic spectrum below
200 nm is known as
a) Vacuum ultra violet region b) Far
UV region c) Low UV region d) Microwave region
Q.4 O/W micro emulsion containing hydrophilic
surfactant produces
a) Translucent emulsion b) Transparent emulsion
c) Milky white emulsion d) Intense white emulsion
Q.5 Which of the following steroids shows
predominant mineralo corticoid action
a) Hydrocortisone b) Spironolactone c) Dexamethone d) Fludrocortisone
Q.6 The factors affecting diffusion current in
polargraphy can be denoted by
a) Nernest equation b)
Ilkovic equation c) Lambert’s law d) Mark-houwink equation
Q.7 Rotasort is equipment used
a) to separate unfilled capsules b) To fix the cap and body of the
capsules after filling
c) To separate the improper
tablets d) To adjust the required compression for
tablets.
Q.8 As per G.M.P. permitted limit of solid contents
in water for injection is
a) 100 ppm b) 1.0 ppm c) 0.1 ppm d) 10.0 ppm
Q.9 Nujol is
a) Hexachlorobutadiene b) Mineral oil c) Perfluorokerosene d) Flurolube
Q.10 Which of the following is a microsomal enzyme
inducer?
a) Indomethacin b) Clofibrate c) Tolbutamide d) Glutethemide
Q.11 Fiducial limit is a term used in
a) Microbiological assay b)
Biological assay c) Chemical assay d) Instrumental methods of assay
Q.12 Phenothiazines are metabolized
a) In hepatic microsomal system by hydroxylation
followed by conjugation with glucoronic acid b) In the liver by oxidation c) In
hepatic microsomal system by reduction
d) In hepatic microsomal system
by oxidation followed by conjugation with glycine
Q.13 Benzodiazepines potentiate
a) The binding of protein to nervous tissue b) The binding of GABA to liver
c) The binding of GABA to
receptors d) The
binding of GABA to carbohydrates
Q.14 Benzylkonium chloride is a germicidal
surfactant which is rendered inactive in the
presence of
a) Organic acid b) Cationic surfactants c) Soaps d) Inorganic salts
Q.15 Enkephalins are
a) Endogenous compounds useful in analgesia
b) Endogenous ligands which are penta peptides that
are localized in same nerve endings
c) Endogenous ligands which are tri peptides that
are present in nervous tissue
d) Endogenous ligands which are
tetra peptides that are present in cardiovascular tissue
Q.16 Benorylate is prodrug, chemically it is
polymeric condensation product of
a) Aluminium hydroxide and aspirin b) An acetyl salicylic ester
of phenol
c) An acetyl salicylic ester of
paracetamol d) An acetyl
salicylic ester of â-naphthol
Q.17 Listed below are some of the common vehicles.
Which one is most appropriate for
the intravenous admixture of ampicillin 500 mg/50
ml?
a) 5 % dextrose injection b) 5 % dextrose
and 0.9 % sodium chloride solution
c) 2.5 % dextrose & 0.45 %
sodium chloride injection d) 0.9 % sodium chloride
inj.
Q.18 Acetonides are prepared to improve the
bioavailability of certain drugs. Which of
the following is available as acetonide?
a) Chlonidine b) Predenisolone c) Pyremethamine d) Triamicinolone
Q.19 Which one of the following indicator is used in
complexometric titration?
a) Crystal violet b) Murexide c) Eosin d) Methyl orange
Q.20 Betamethasone is
a) 9α-fluoro-11β, 17α,21-trihydroxy-16β-methyl
pregna-1, 4- diene-3, 20-dione
b) 9α-fluoro-12β, 13α,21-trihydroxy-16β-methyl
pregna-1, 4- diene-3, 20-dione
c) 9α-fluoro-11β, 17α,21-trihydroxy-16β-methyl
estra-1, 4- diene-3, 20-dione
d) 9α-fluoro-11β, 17α-dihydroxy-16β-methyl
pregna-1, 4- diene-3, 20-dione
2. Fill in the blanks
a) The anti-inflammatory agents sulindac has the
closest structural similarity to 1….
b) A long polypeptide which possess potent analgesic
activity and found in the Pituitary and
hypothalamus is………
c) Aminophylline I.P. contains theophylline and
3……..
d) Radiopharmaceuticals are filled up in suitable
containers in a protected …4.. laminar flow
cabinet.
e) Efficiency of a filter used for sterilization is
determined by its……
f) The finger print region in
I.P. spectrum ranges from 6……cm-1.
g) 7….is the ideal micro-encapsulation process for
thermo labile ingredients.
h) Spinning of a nucleus
perpendicular to the applied field is known as 8……
i) The test organism for the microbiological assay
of Chloramphenicol I.P is..9…
j) Spironolactone is
competitive antagonist of …10….
k) Colchicine is an alkaloid obtained from ….11………..
l) A typical auxin of plant which is found in
growing tissue is……12…..
m) The largest peak in the mass
spectrum is known as…..13….
3. State whether the following are true or false
a) Quinidine is often given intra-muscularly.
b) Micropore cellulose membrane filters are disposed
after use by burning.
c) The glass electrode used in
potentiometry should not be used in aqueous media.
d) Lidocaine can be given by continuous intravenous
infusion.
e) Acetazolamide is a
sulfonamide type drug used as anti-bacterial.
f) Liquids containing water above 5 % and low
molecular weight water soluble organic compounds are not encapsulated in soft
gelatin capsule.
g) Neutral molecules produced in the fragmentation
cannot be detected in the mass
spectrometer.
h) Stable and metastable polymorphs are only induced
in the preparation of Chloramphenicol suspension.
i) Dimethyl sulphoxide is used as permeation
inhibitor in transdermal preparations
j) The main oxidation product of â-carotene is 2
molecular portion of geronic acid.
Hence it shows the presence of
á-ionone ring structure.
k) Thymol and menthol gives a violet colour reaction
with neutral ferric chloride solution.
l) Dry mixtures are the common paediatric dosage
forms, because of their extended half life.
m) The reversible oxidation and reduction system of
Ascorbic acid accounts for its biological
function.
n) Digitalis leaves, after collection should be
dried as rapidly as possible at a temperature of
about
600C.
o) The process of gel filtration
involves separation of materials on the basis if particle size.
4. Match the followings.
Q.1 The biological indicators mentioned bellow are
used for specific type of sterilization
listed a to e. Match them correctly.
i) Bacillus subtilis a) Ionizing
radiation
ii) Bacillus stearothermophilus b) Dry heat sterilization
iii) Bacillus pumulis c) Filtration
iv) Pseudomonas diminuta d) Moist heat sterilization
e) Gaseous sterilization
Q.2 Following are some of the starting materials for
the synthesis of compounds listed a
to e. Match them correctly.
i) γ-Picoline a)
Diethyl carbamazine
ii) 4-nitro-2-amino toluene b)
Isoniazid
iii) Piperazine and diethyl carbamoyl chloride c) Chlorpromazine
iv) 2-chloro Phenothiazine d)
Ditiazem
e) P.A.S.
Q.3 Microscopical characters a to e associated with
the plant drugs listed below. Match
them correctly.
i) Elettaria cardmomum a)
Rhytodomes
ii) Quallaia saponaria b)
Clothing and glandular trichomes
iii) Digitalis purpurea c) Thin membraneous arillus
iv) Atropa belladonna d)
Stomata of anisocytic type
e) Concave midrib
Q.4 The equipments listed a to e are used for the
identification of the properties of
aerosol mentioned below. Match them correctly.
i) Particle size determination a) Pycnometer
ii) Identification if propellants b) Rotational
viscometer
iii) Stability of foam c)
Tag open cup apparatus
iv) flash point d)
Infrared spectroscopy
e) Cascade Impactor
Q.5 Match the terms mentioned from a to e with
corresponding spectrophotometric
methods
i) IR a)
Antibonding orbital
ii) Mass spectra b) Stretching and
bending
iii) NMR c)
Metastable ions
iv) UV d) Chemical shift
e) Depolarization
Q.6 Pharmacological activity of certain well known
plant drugs are listed a to e. Match
them correctly.
i) Papaverine a) Weak
analeptic
ii) Camphor b)
Vasodilator
iii) Veratrum alkaloids c) Antineoplastic
iv) Vincristine d) Central
vasoconstrictor
e) Anxiolytic
Q.7 Given below are some of the common reactions
their definations are listed a to e.
Match them correctly.
i) Saponification a) Reaction of acids and
bases to form salt and water
ii) Esterification b) Reaction of an oil
with an alkali to form soap and glycerol
iii) Neutralization c) Reaction in which
hydrogen atoms are added to double bonds
iv) Hydrolysis d) Reaction in which
hydroxyl group is replaced by alkoxy group
e)
Reaction of salt or ester with water to form acids and bases or alcohol
Q.8 Listed below are some of the important drugs.
Classify them as per the relevant
Schedules of Drugs and Cosmetics Act.
i) Chlorpropamide
a) Schedule G
ii) Betamethasone benzoate b) Schedule M
iii) Amaranth c)
Schedule H
iv) Dexamphetamine d) Schedule Q
e) Schedule X
Q.9 Match the coatings given below with their
corresponding techniques listed a to e.
i) Compression coating a) Air in the coating pan
is replaced with nitrogen
ii)Dip coating b) Application of coating to conductive
substance
iii) Electrostatic coating c) Acid insoluble coating
iv) Vacuum film coating d) A tablet within a
tablet
e) Repeated coating and drying
Q.10 The most appropriate pharmacological actions of
the following drugs are listed a to
e. Match them correctly.
i) Verapamil a) Calcium
channel blocker
ii) Propranolol b) coronary
vasodilator
iii)Dipyridamole c) β-adrenergic
blocker
iv) Hydralazine d) Arteriolar
vasodilator
e) Arteriolar and venous vasodilator
Answer Key-1994 (Multiple Choice)
1.b 2.a 3.b 4.b 5.d 6.b 7.a 8.d
9.b 10.d 11.a 12.a 13.c 14.c 15.b 16.c 17.d 18.d 19.b 20.a
Fill in the blanks
1. Indomethacin 2.β-endorphins 3. ethylenediamine 4.
reverse 5. pore size 6. 1600-600 cm-1
7. air suspension 8. precession I.E.Coli 9.
aldosterone 10.colchicum seed (Colchicum autumnale)
11. Indole-3-acetic acid 12. base peak 13.
hypotensive effect of metabolite diethylamino ethanol
14. ionotropic effect 15.
mercuric acetate 16. Kino-Matic viscosity 17. protease 18. ascorbic
True/False
1. T 2.F 3.F 4.T 5.F 6. T 7.T
8.F 9.F 10.F 11.F 12.F 13.T 14.T 15T
Match the columns
1. (1) b (2) d (3) a (4) c 2. (1) b (2) e (3) a
(4) c
3. (1) c (2) a (3) b (4) d 4. (1) e (2) d (3) b
(4) c
5. (1) b (2) c (3) d (4) a 6. (1) b (2) a (3) e
(4) c
7. (1) b (2) d (3) a (4) e 8. (1) a (2) c (3) d (4) e
9. (1) e (2) c (3) b (4) a 10. (1) a (2) c (3) b
(4) d
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