1.Choose the correct answers.
Q.1 One of the drug is excreted primarily by renal
tubular secretions. Identify
a) Gentamycin b) Kanamycin c) Tetracycline d) Carbinicillin
Q.2 Identify one of the cancer chemotherapeutic
agent which is an anti metabolite
a) Fluorouracil b) Nitrogen mustard c) Cyclophosphamide d) Chlorambucil
Q.3 Agents useful in the treatment of bronchial
asthma usually
a) block both α and β adrenergic receptors
b) Stimulate α receptors but block β receptors
c) Stimulate β receptors but block α receptors
d) Stimulate α and β receptors
Q.4 The anti arrhythmic drug Quinidine
a) (+) Stereoisomer of Quinine b) (-) Stereoisomer of Quinine
c) (±) Racemic mixture of
Quinine d) none of the
above
Q.5 β-Carboline ring system is present in
a) Emetine alkaloid b)
Cortisone acetate c) Despiridine molecule d) Atropine alkaloid
Q.6 License for wholesale of drugs specified in
Schedule C and C1 are issued in form
a) 20 A b) 20 B c) 21 B d) 22 A
Q.7 The principal constituent Anethole (50 – 60 %)
and Fenchone (18 – 20 %) is present
in the volatile oil obtained from
a) Fruits of Ammi visnaga-Linn b) Fruits of Foeniculum
capillaccum – G (F. vulgare)
c) Fruits of Carum carvi-Linn d) Fruits of Anethum
Graveolens-Linn
Q.8 Caffeine on oxidation with KClO3/HCl gives
a) Trimethyl alloxan and urea b) Methyl alloxan
and dimethyl urea
c) Dimethyl alloxan and methyl
urea d) none of these
Q.9 Out of the following types of adverse drug
reactions is not believed to be dose
related phenomena.
a) Side effects and toxic reactions b) Toxic reactions and
hypersensitivity
c) Side effects and
hypersensitivity d)
Hypersensitivity and idiosyncrasy
Q.10 Green bones are used for the preparation of a
gelatin of the type
a) A b) B c) C d) A and B
Q.11 In ROTOFIL is used for filling
a) powders b) pellets c) liquids d) corrosive liquids
Q.12 Gelatin and glycerin are used for the
preparation of Lamellae in a specified ratio.
Identify the correct ratio
a) 1:1 b) 5:1 c) 9:1 d) 10:1
Q.13 The Shick test is used to determine
susceptibility to
a) Measles b) diphtheria c) Polio d) typhoid
Q.14 One of the following general characteristics is
not true for alkaloids
a) Nitrogen in the heterocyclic nucleus b) Good solubility in organic
solvents
c) pKa less than 7 d)
Exhibit optical activity
Q.15 Silver/Silver chloride electrode consist of
a) metallic silver coated with a layer of silver
chloride
b) Polished platinum wire coated with silver
chloride
c) silver wire dipped in a saturated solution of
silver chloride
d) two electrodes one of silver
and other of silver chloride
Q.16 In gel permeation chromatography, molecules are
separated on the basis of their
a) Chemical nature b)
Size and shape c) Adsorptive
properties d) Partition coefficient
Q.17 According to Pauli exclusion principle, spin of
two electrons in the same orbital are
a) parallel to one another b) perpendicular to one
another
c) Opposite to each other d) supporting one another
Q.18 Vaccines and toxoids are precipitated and
absorbed on to aluminium hydroxide or
other suitable media. This process results in a
dosage form that in comparation to fluid form
a) more effective orally b) absorbed slowly c) stability is increased d) irritation is lost
Q.19 In order to produce characteristic
pharmacological action, a drug must always
a) reach high blood levels b) absorbed from GIT readily
c) achieve adequate concentration at the side of action d) excrete unchanged in urine
Q.20 The Wurster process can be used to
a) coat tablets
b) determine the disintegration
time
c) gas sterilize parentral solutions
d) automatic filling
of capsules
2. Fill in the blanks
1. In multistation process, the portion head that
hold the upper and lower punches are
called the
upper and lower……..respectively.
2. In tablet disintegration test, the wire mesh of
the tube at its lowest point is atleast
….mm above the bottom of the beaker.
3. Roller compactor is used in large
scale…..granulation.
4. Chemical name of propellant
114 is……………….
5. In non aqueous injections Sesame oil and…..oil
are used as solvent
6. 1-(p-chlorobenzoyl)-5-methoxy-2-methyl
Indole-3-acetic acid is commonly known as..
7. Rubifium chloride injection (contains Rb-86) is
used to determine….blood flow.
8. Benzil on treatment with
urea gives…..which is anticonvulsant.
9. Ethyl phenyl malonamide on condensation with
formaldehyde gives…………
10. In the outer part of the…..numerous ovoid
Schizo-lysigenous oil glands are present in
clove bud.
11. The brown seed of Nutmeg is surrounded by a crimson
reticulate…..which is
stripped
off and dried to form mace.
12. Terbutiline sulphate is a
……agonist.
13.Salicylates and other anti-inflammatory drugs
irreversibly inactivate the enzyme
…..responsible
for the conversion of arachidonic acid to prostaglandin.
14. The temperature above which cloudiness suddenly
appears for non-ionic surfactant in
solution is known as…………..
15. Dragendorff’s reagent used in testing alkaloids
is chemically……..
16. IR absorption spectra of aldehydes, ketones,
carboxylic acids and their derivatives
contain one absorption common peak due
to………….
17.When the molecular weight of a substance is
unknown, the intensity of absorption is
expressed
as………….
18. The frequency of rotating magnetic field and the
frequency of the precessing nucleus
become equal they are said to
be in…………..
19. A rod of silicone carbide 6 – 8 mm in diameter
and 50 mm in length heated to a
temperature of 13000C gives……………………..radiation.
20. Osmotic pellets are extensively
used as…………
3. State whether the following are True or False
1. The chloro group in chlortetracycline is in 8th
position.
2.Ethacrynic acid is high ceiling (loop) diuretic
which inhibits electrolytic reabsorption in
the thick ascending limb of the loop on
Henle
3. Pharmaceutical pectin differs from commercial
pectin because it does not contain
sugar and
organic acid.
4. antihistamines stimulate the
metabolism of endogenous histamine.
5. Vitamin E appears to be compatible with mineral
supplement such as calcium and iron
6. Hepatic clearance is the sum of hepatic metabolic
clearance and biliary clearance.
7. The efficiency of a tumbling mixer is highly
dependent on the speed of rotation.
8. Liquid glucose is obtained by complete hydrolysis
of starch.
9. Ethylene oxide sterilization
is suitable for rubber closures.
10. Samples can be handled in the form of solid,
liquid or gas in mass spectrometry.
11. A photo cathode operates on the principle that
electrons are emitted from certain
material
in direct proportion to the number of light quanta striking on the surface of
the
material.
12. Purine occurs in free nature.
13. A guard column is used to HPLC to pre saturate
the mobile phase with stationary
phase.
14. Balsams are resinous mixtures that contain large
proportions of benzoic acid,
cinnamic
acid, salicylic acid or esters of these acids.
15. The state pharmacy council is established by
state drugs controller.
4. Match the followings
Q.1 Match the followings descriptions given A to F
with product mentioned below:
1) Agar a) Chief carbohydrate
from macrocystis pyrifera
2) Carageenan b) Dried exudates from Astragalus’s
gummier
3) Tragacanth c) Closely related hydrocolloids
from Chondrus cripsus
4) Algin d) Hydrophilic colloid
from Geledium cartilagenum.
e)
Powdered endosperm of the seeds of Cyamopsis tetragonolobus
f)
Carbohydrates from the Rhizomes a zinger sps.
Q.2 Listed are drugs 1 to 4. Their appropriate
antihypertensive mechanism are given in A
to F. Match them correctly.
1) PIDALOL a) Vasodilator
2) MINOXIDIL b) Angiotensin converting enzyme
3) CAPTOPRIL c) Diuretic
4) AMILORIDE d) β – blockers
e)
Centrally acting α2- adrenoceptor agonist
f)
Potassium induction
Q.3 Listed below are substances which are assayed by
organisms mentioned in A to E.
Match them correctly.
1) Crystal Voilet I.P. a) Pasteurella pestis
2) Ampicillin I.P. b) Bacillus cereus
3) Plague Vaccine I.P. c) Micrococcus luteus
4) Rifampicin I.P. d) Staphylococcus aureus
e)
Lactobacillus aureus
f)
Bacillus subtilis
Q.4 Important Psychoactive phenothiazines listed
below have the following side chains at
10-positions, which are given in
1) CHLORPROMAZINE a) 3-(4-methyl
piperazine-1-yl)propyl
2) PROCHLORPERAZINE b) 2-(1-methyl piperid-2-yl)
ethyl
3) THIORIDAZINE c) 3-[4-(2-hydroxy
ethyl) piperazine-1-yl)]propyl
4) PERPHENAZINE d) Dimethylamino ethyl
e) Dimethylamino propyl
f) Dimethylamino butyl
Q.5 Listed below are the physical forms of the
medicaments which normally show the
rheological properties given A to F. Match them
correctly.
1) Viscous oils a)
Dilatant flow
2) Gellies b)
Plug flow
3) Colloids c) Newtonian flow
4) Concentrated solid suspension d) Plastic flow
e) Pseudo plastic flow
f) Non-Newtonian flow
Answer Key-1995 (Multiple Choice)
1.d 2.a 3.d 4.a 5.c 6.c 7.b 8.c
9.d 10.b 11.b 12.b 13.b 14.c 15.c 16.b 17.c 18.c 19.a 20.a
Fill in the blanks
1. turrets 2. 25 3.
dry 4. dichlorotetrafluoroethane
5.arachis oil 6.Indomethacin 7. Myocardial 8. Phenytoin 9. primidone 10. hypanthium 11.arrilode 12. β2 13. Archidonic acid cycloxygenase 14. cloud point 15. potassium bismuth iodide
16. Carbonyl group stretching 17. E1% 1cm 18. resonance 19.infra red radiation
20. sustained release
True/False
1. F 2.T 3.F 4.F 5.F 6. F 7.T
8.F 9.F 10.T 11.T 12.F 13.F 14.F 15F
Match the columns
1. (1) d (2) c (3) b (4) a 2. (1) d (2) a (3) b (4) c
3. (1) d (2) c (3) a (4) f 4. (1) e (2) a (3) b (4) c
5. (1) c (2) e (3) f (4) a
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