GATE-1996 (Pharmaceutical Science)

1.Choose the correct answers.

For each question given below four answer are provided out of which only one is correct.

Q.1 CLONIDINE HYDROCHLORIDE-IP is

a) Monoamine oxidase inhibitor which contains an imidazoline ring system

b) arterial and venous vasodilator which contains imidazoline ring system

c) monoamine oxidase inhibitor which contains Pyrimidine ring system

d) monoamine oxidase inhibitor which contains phthalazine ring system

Q.2 Borntrager’s test is performed for identification of

a) Digitoxin                 b) Reserpine              c) Digoxin                d) Dianthrone of rhein

Q.3 The electrode system employed in potentiometric titrations of acids by non-aqueous

method in basic solvents.

a) Glass Calomel electrodes                     b) Antimony-Glass electrodes

c) Glass-Antimonyelectrodes                   d) Antimony-Calomel electrode

Q.4 The drug NALAXONE

a) Produces morphine like activity           b) Produces respiratory depression

 c) induces constipation                            d) precipitates withdraw symptoms in morphine addicts.

Q.5 Phenyl alanine, ornithine and methionine are involved in the biogenesis of

a) LYSERGIC ACID         b) RESERPINE         c) l-HYOSCYAMINE            d) PAPAVERINE

Q.6 The area under the serum concentration time-curve represents the

a) biologic half life the drug                 b) amount of drug that is cleared by the kidneys

c) Amount of drug absorbed                 d) amount of drug excreted in the urine.

Q.7 An Interference filter consists of

a) an iron plate coated with selenium      b) a layer of silver deposited on glass coated with MgF2

c) a tungsten plate coated with silver oxide             d) a solid sheet of glass coloured by pigment

Q.8 which of the following is the first process that must occur before a drug can become

available for absorption from a tablet dosage form?

a) dissolution of the drug in the G.I. fluids               b) dissolution of the drug in the epithelium

c) Ionization of the drug                                            d) disintegration of the tablet.

Q.9 PROPRANOLOL

a) reduces myocardial oxygen consumption              b) β1-receptor selective blocker

c) has intrinsic sympathomimetic activity

d) is a hypotesive agent in patients with normal blood pressure

Q.10 2-bis-(2-chloroethyl)amino per hydro 1, 3, 2-oxazephosphorinane is an

a) anti-metabolite        b) alkalyting agent        c) anti-tubercular agent    d) anti arrhythmic agent.

Q.11 A moiety of a molecule responsible for selective absorption of radiation in a

specific range is called is

a) auxochrome                   b) catalyst                c) chromophore         d) elicitor

Q.12 Chlorodiazepoxide is synthesized from

a) p-chloroaniline and Benzyl chloride           b) p-chloroaniline and Benzoyl chloride

c) p-Chloroaniline and Benzidine                   d) p-nitroaniline and benzoyl chloride

Q.13 Tablets are placed into a coating chamber and hot air is introduced through the

bottom of the chamber. Coating solution is applied through the atomizing nozzle from

the upper end of the chamber. This technique is called

a) sealing before sugar coating                b) coating by air suspension

c) spray pan coating                                 d) chamber coating

In the following three questions match each items 1, 2, 3 and 4 on the left, with an

appropriate item on the right.

Q.1 Name the following terms with the phytoconstituents mentioned below.

1) OPIUM                                 a) Tropane alkaloid

2) ERGOTAMINE                    b) cardiac glycosides

3) SCOPOLAMINE                  c) latex of poppy capsules

4) GINSENOSIDES                  d) oxytoxic effect

                                                    e) Adaptogenic and tonic

                                                     f) Cyanogenetic aglycone

Q.2 Formulation of hard gelatin capsule may necessitate the additive listed 1 to 4. their

functions are given in A to F. match them.

1) Diluents                      a) For preventing absorption of moisture by hygroscopic substances

2) Protectives                  b) For increasing the bulk

3) Glidants                      c) To prevent cross contamination

4) Antidusting                 d) For regulating the flow

                                        e) For avoiding weight variation

                                         f) For Bacterial resistance

Q.3 For the drug listed 1 to 4, mechanism of action is indicated from A to F. Match them.

1) VINCRISTINE              a) Macrocyclic antibiotic which inhibits DNA dependent RNA  

                                               polymerase

2) STREPTOMYCIN        b) An antibiotic containing nitro group which bind to 50S ribosomal

                                              subunit

3) CHLORAMPHENICOL     c) A dimeric indole alkaloid which binds avidly to tubuline, a                   

                                                    class of protein that form mitotic spindle.

4) RIFAMPICIN                      d) An aminoglycosidic antibiotic, capable of binding to 30S

                                                     ribosomal subunit

                                           e) A Quinoline alkaloid which inhibits the growth Plasmodium Vivex

                                            f) a naphthacene antibiotic which inhibits cell wall synthesis

Answer Key-1996 (Multiple Choice

1.b 2.d 3.a 4.d 5.c 6.c 7.b 8.d 9.a 10.b 11.c 12.b 13.b

Match the columns

1. (1) c (2) d (3) a (4) e                         2. (1) b (2) a (3) d (4) c

3. (1) c (2) d (3) b (4) a