GATE-1997 (Pharmaceutical Science)

1.Choose the correct answers.

Q.1 The hydrolytic product of STREPTOMYCIN with methanolic hydrochloric acid is

given below. Identify the correct one

a) Streptidine + Streptose + N-methyl glucosamine

b) Streptidine + Strepto biosa--minide dimethyl acetal

c) Streptamine + Streptose + N-methyl glucosamine

d) Streptamine + Streptose dimethyl acetal + N-methyl glucosamine

Q.2 One of the following drug interfere with cellular metabolism, especially the synthesis

of mycolic acid. Identify

a) CHLORAMPHENICOL b) PYRAZINAMIDE c) ISONICOTINIC ACID

HYDRAZIDE d) NICOTINAMIDE

Q.3 A synthetic sweetening agent which approximately 200 times more sweeter than

sucrose and has no after taste

a) Saccharin b) Aspartame c) Cyclamine d) Sorbitol

Q.4 In capsules, ROTOSORT is used for

a) filling powder into capsules b) filling liquid into capsules

c) filling pellets into capsules d) sorting the filled capsules

Q.5 Shellac is used for the purpose of coating tablets as

a) Polishing agent                              b) film coating agent

c) enteric coating agent                      d) sub coating agent for sugar coating

Q.6 Listed below are structures of some drugs. One of them prevents the incorporation

of PABA into folic acid. Identify.

 

Q.7 In quantitative T.L.C., radioactive material can be studied by

a) visual comparison  b) densito meter c) gravimetry d) Geiger counter

Q.8 One of the following ingredients which improves the flow properties of granules

a) Glidant b) emollient c) lubricant d) Surfactant

Q.9 The wavelength sources in NMR spectrometer is

a) Goniometer                            b) radiofrequency oscillator

c) high voltage generator          d) Klystron oscillator

Q.10 One of the following materials is used for the preparation of master grating. Identify

a) glass               b) iron               c) aluminium              d) teflon

Q.11 Benzathine penicillin is

a) an equimolecular composition of Amoxicillin + N,N- dibenzyl ethylene diamine

b) a molecular complexation of benzyl penicillin + N,N- dibenzyl ethylene diamine

c) equimolar complexation of Cloxacillin + ethylene diamine

d) equimolar proportion of Amoxicillin + diethylamine

Q.12 Schick test is performed to ascertain susceptibility to

a) tetanus          b) diphtheria              c) mumps                 d) syphilis

Q.13 Which of the following commonly available large volume dextrose solutions for

Intravenous use is isotonic

a) 25% W/V                b) 50% W/V               c) 10% W/V                 d) 20%W/V

Q.14 The term bioavailability refers to the

a) relationship between the physical and chemical properties of a dug and the systemic  

    absorption of the drug

b) measurement of the rate and the amount of the therapeutically active drug that reaches the

     systemic circulation

c) movement of drug into the body tissues over time

d) dissolution of a drug in the gastrointestinal tract

Q.15 Among the propellants used in Aerosol one of the following is used for topical

pharmaceutical aerosols

a) Trichloro monofluoro methane                        b) Dichloro difuoloro methane

c) Dichloro tetra fluoro methane                           d) Propane

Q.16 The principle structural component of the cell wall of bacteria is made up of

a) simple protein                                         b) peptidoglycan polymer

c) complex polysaccharides                       d) glycoprotein

Q.17 which of the following has the highest degree of ionization in an aqueous solution?

a) Aspirin pKa – 3.5                        b) Indomethacin pKa – 4.5

c) Warfarin pKa – 5.1                      d) Ibuprofen pKa - 5.2

Q.18 Tetracycline is avoided during pregnancy because

a) it is teratogenic                                                      b) it may affect the bone growth of foetus

c) it causes discoloration of mother’s teeth              d) it may cause abortion

Q.19 Xenoboitics that does not cause Nephrotoxicity

a) STREPTOZOCIN     b) CISPLATIN            c) GENTAMYCIN            d) ISONIAZID

Q.20 Which of the following functions of ì opioid receptors?

a) decrease Noradrenalin release                           b) decrease Dopamine release

c) decrease Serotonin release                                 d) decrease Acetyl choline release

Q.21 Assume that a typical type of Cancer is susceptible to an individual drug. Listed below are some therapeutic combination of anti cancer drugs which are rationale one. Identify

a) THIOTEPA and PREDNISONE                 b) DOXORUBICIN and METHOTRAXATE

c) CHORAMBUCIL and MEPHALAN          d) none of these

Q.22 One of the following emissions from the decay of Radio nuclides is commonly used in sterilization. Identify

a) GAMMA b) X-ray c) ALPHA d) POSITRON

Q.23 Clinically available anti-cancer agents have one of the underlaying mechanisms of action, they act by

a) improving body defence mechanism                      b) Inhibition of cell wall synthesis

c) receptor site blockade of cancer cell content           d) cell growth inhibitor

Q.24 Listed below are some of the common Radio nuclides used in Nuclear Pharmacy.

Which one is generator produced.

a) 201 Tl                   b) 67 Ga                   c) 133 Xe                              d) 99m Tc

Q.25 Small pox Vaccine contains

a) Living Virus Vaccina                               b) Living culture of B.C.G.

c) Attenuated staphylococcus                       d) Living virus of Hepatitis

Q.26 The solution strength of Ca++ in terms of mg/L, for a Calcium injection which

contains 5 m Eq Calcium (Ca++) per 100 ml is given below, Identify the correct one

[At. Wt. Ca++ = 40]

a) 150                   b) 500                           c) 750                              d) 1000

Q.27 Listed are some of the drug intermediates. Choose the correct structural name of

PROCAINAMIDE

a) p-nitro benzyl chloride and Diethyl amino ethylamine

b) p-nitro benzyl chloride and Dimethyl amino ethylamine

c) p-nitro cinnamoyl chloride and Diethyl amino ethylamine

d) p-nitro benzene and Diethyl amino ethylamine

Q.28 Choose the correct name of Digitoxigenin

a) 3β, 14β, 16β- trihydroxy cardenolide              b) 3β, 12β, 14β- trihydroxy cardenolide

c) 3β, 14β, - di hydroxy cardenolide                    d) 1,3,5,11α 14β, 19β- hexahydroxy cardenolide

Q.29 2,6 dimethyl aniline and chloro acetyl chloride are the starting compounds of the

synthesis of one of the following drugs. Choose the correct one

a) LIDOCAINE        b) PRILOCAINE          c) BUPIVACAINE           d) CINCHOCAINE

Q.30 Choose the correct Geneva name for TRANYL CYPROMINE

a) (-) trans-2-phenyl cyclopropylamine              b) (+) trans-2-phenyl cyclopropylamine

c) (±) cis-2-phenyl cyclopropylamine                d) (±) trans-2-phenyl cyclopropylamine

Q.31Intake of which of the following should be avoided by a patient taking an oral-anticoagulant

a) CYNOCOBALAMINE   b) THIAMINE     c) MENADIONE       d) TOCOPHEROL

Q.32 Ellipsoidal Schizo-lysigenous oil glands are important diagnostic characteristic of

a) ERGOT           b) GINSENG                c) CINNAMON               d) CLOVE

Q.33 Catecholamines act by

a) decrease the amount of glucose released into blood

b) increase the utilization of glucose by muscle

c) increase the amount of glucose released into blood

d) decrease the amount of glucose released into muscle

Q.34 HYOSCYAMINE an alkaloid obtained from atropa belladonna

a) readily racemises to atropine with ethanolic alkali. Atropine is (±) Hyoscyamine

b) readily disintegrates into atropine with acid solution. Atropine is (±) Hyoscyamine

c) readily rearrange to atropine with ethanolic alkali. Atropine is (±) Hyoscyamine

d) none of these

Q.35Identify the correct molecule which controls the biosynthesis of proteins in living organisms

a) DNA                         b) RNA                      c) PURINES                         d) PYRIMIDINES

2. Match the following:

In the following sub questions, match each items 1, 2, 3 and 4 on the left with an appropriate item on the right

Q.1 Listed below are substances which are assayed by methods mentioned in (a) to (f).

Match them

1) Ascorbic Acid Tablet I.P.                a) Fluorimetry

2) Thiamine Hydrochloride                 b) Spectrophotometry

3) Calcium Pantothenate I.P.               c) Ceric ammonium sulphate oxidation

4) Pyridoxine Hydrochloride I.P.        d) Complexometry

                                                             e) Non aqueous

                                                             f) Gravimetry

Q.2 The diagnostic features of crude drugs are given in the right hand side of column given in (a) to (f). match them

1) Trichome                   a) Two similar cells placed with their long axis parallel and having     

                                                 smaller intracellular space

2) CICATRIX                 b) Epidermal cells which do not have any define function

3) STOMATA               c) An elongated tubular outgrowth of an epidermal cell

4) MESOPHYLL          d) Trichomes having fallen or been rubbed off leaving scar

                                 e) The whole of the parenchymatous ground tissue between two epidermises

                                  f) Flat and has one or more rows of palisade

Q.3 Some types of drugs are listed below, the specific examples are given in (a) to (f).

Match them

1) ANTIFOLATE                          a) VINBLASTINE

2) PURINE analogues                    b) THIOGUANINE

3) PYRIMIDINE analogues           c) 5-FLUORACIL

4) ANTIMITOTIC                         d) METHOTREXATE

                                                        e) ACTINOMYCIN

                                                         f) CYTARABINE

Q.4 Hetrocyclic systems (1-4) and the natural products in which they are present is given

in (a) to (f). Match them

1) IMIDAZOLE                                 a) RESERPINE

2) â-CARBOLINE                              b) PILOCARPINE

3) HETEROSTEROIDAL                  c) CONESSINE

4) ISOQUINOLINE                           d) ERGOTAMINE

                                                            e) PAPAVERINE

                                                            f) SCOPOLAMINE

Q.5 Starting materials used in the synthesis of the following reagents are given in (a) to (f). Match them

1) MEPYRAMINE MALEATE                  a) AZOCINE and Chloromethyl cyanide

2) GUANTHIDINE SULPHATE                b) 10-H Dihydro 5-H dibenz[b-f]azepine

3) ISOXSUPRINE HYDROCHLORIDE    c) 5-OXO-10-H dihydro 5-H [a-d] cycloheptene

4) IMIPRAMINE HYDROCHLORIDE      d) 4- hydroxy nor epinephrine

                                                                      e) benzaldehyde and 2-chloro pyridine

                                                                      f) 4-methoxy benzaldehyde and 2 amino pyridine

Q.6 Listed below are some tests carried out to identify the constituents given in (a) to (f). Match them

1) Benedict’s test                     a) Bile salt

2) Hay’s test                            b) Calcitriol

3) Gimelin’s test                      c) Bile pigments

4) Sulkowitch test .                  d) Urea

                                                 e) Ketone bodies

                                                  f) Glucose

Q.7 Antibiotics and their biochemical origin are given below. Match them

1) CYCLOSERINE                 a) Two amino acid units

2) CEPHALOSPORIN           b) Single amino acid

3) NEOMYCIN                       c) Sugars

4) ERYTHROMYCIN            d) Polypeptides

                                                 e) Acetate or propionate

                                                 f) Polycyclic units

Q.8 Match the following relationship correctly

1) HYPOKALEMIA                  a)Biotransformation prior to eliciting Pharmacological response

2) SPIRONOLACTONE           b) Competitive antagonist of Aldosterone

3) RHODOPSIN in Retina         c) Reduction of Serum K level

4) PRODRUG                             d) Vitamin A

                                                     e) BIOTIN

                                                     f) Competitive antagonist of cortisone

Q.9 In parentral products, listed below are some ingredients. Their main functions are given in (a) to (f). Match them

1) THIOMERSAL                      a) chelating agent

2) ASCORBIC ACID                 b) Buffer

3) EDTA salts                             c) Anti oxidant

4) Sodium chloride                     d) Antimicrobial agent

                                                    e) Vehicle

                                                    f) Tonicity adjusting agent

Q.10 Size, shape and mode of arrangements in typical of certain Microorganisms. Match

them correctly

1) STREPTOCOCCI                      a) Comma and S shaped form

2) SARCINA                                  b) Gram positive arranged in chains

3) BACILLUS ANTHRACIS        c) Multiples of eight

4) VIBRIOS and SPIRILLA          d) Large bacilli, rectangular and gram positive

                                                        e) Gram negative cocci

                                                         f) Rod shaped-Acid fast

Answer Key-1997 (Multiple Choice)

1.a 2.c 3.b 4.d 5.c 6.a 7.d 8.a 9.b 10.c 11.b 12.b 13.b 14.b 15.d 16.b 17.a 18.b

19.d 20.b 21.d 22.a 23.d 24.d 25.a 26.d 27.a 28.c 29.a 30.d 31.c 32.d

33.c 34.a 35.a

Match the column

1. (1) c (2) a (3) d (4) e              2. (1) c (2) d (3) a (4) e

3. (1) d (2) b (3) c (4) a              4. (1) b (2) a (3) c (4) e

5. (1) f (2) a (3) d (4) b               6. (1) f (2) a (3) c (4) b

7. (1) b (2) a (3) c (4) e               8. (1) c (2) b (3) d (4) a

9. (1) d (2) c (3) a (4) f               10. (1) b (2) c (3) d (4) a