Notes for Pharmacy competitive examination-3 (Pharmaceutical Science)

• CAPSULE NO & THEIR APPROXIMATE CAPACITY IN mg & ml

000 - 950 - 1.37

00 - 650 - 0.95

0 - 450 - 0.68

1 - 300 - 0.50

2 - 250 - 0.37

3 - 200 - 0.30

4 - 150 - 0.21

5 - 100 - 0.13

PROPORTIONS REQUIRED FOR A PRIMARY EMULSION

(oil:water:gum)

Fixed oils :- 4:2:1

Volatile oils:- 2:2:1

Mineral oils:- 3:2:1

Oleoresins:- 1:2:1

CODE: LPSO ( apply this for tweens & spans)

for eg .. spans 20 mean sorbitan mono laurate

tween 80 mean Polyoxyethylene sorbitan monooleate

L : Laurate - 20

P : Palmitate - 40

S : Stearate - 60

O : Oleate - 80

SOLUBILITY

DESCRIPTIVE TERM - APPROX VOL OF SOLVENT IN ml/gm OF SOLUTE

Very soluble - less than 1

Freely soluble - 1 - 10

Soluble - 10 - 30

Sparingly soluble - 30 - 100

Slightly soluble - 100 - 1000

Very slightly soluble - 1000 - 10,000

Practically insoluble - more than 10,000

STORAGE TEMPERATURE

Cold - 2 - 8 degree centi

Cool - 8 - 25

Room - temp prevailing in the working area

Warm - between 30 - 40

Excessive heat - > 40 degree

SUCROSE BASED DILUANTS

Dipac - 97 % sucrose + 3% moddified dextrose

Nutab - 95 % sucrose + 4 % invert sugar

Sugar tab - 90 - 93 % sucrose + 7 - 10 % invert sugar

Compressibility index / carrs index = tapped density - bulk density / tapped density

hausners ratio = tapped density / bulk density

% CI                FLOW CHARACTER                      HAUSNER RATIO

< or = 10                  excellent                                             1 - 1.11

11 - 15                       good                                                1.12 - 1.18

16 - 20                       fair                                                   1.19 - 1.25

21 - 25                        passable                                          1.26 - 1.34

26 - 31                        poor                                                  1.35 - 1.45

32 - 37                        very poor                                         1.46 - 1.59

>38                            very very poor                                      > 1.6

ANGLE OF REPOSE                      FLOW CHARACTER

25 - 30                                  -                    Excellent

31 - 35                                  -                     Good

36 - 40                                   -                     Fair

41 - 45                                  -                     Passable

46 – 55                                   -                     poor

56 - 65                             -                               Very poor

>66                                -                                  very very poor

Types of Glass used in Pharmaceutical Industries

Parenteral Use

Type I Glass:

Highly Resistant Borosillicate.

Used for Buffered and Unbuffered aqueous solution.

Type II Glas:

Highly Resistant Sodalime glass.

Buffered aqueous solution below pH 7.0

Type III Glass:

Moderately Resistant Sodalime glass.

Used for dry powder and oily solution.

Non-Parenteral Use

Type IV Glass:

General Purpose Sodalime glass.

Not for parenteral, for tablet,liquid oral and externals.